ArticleIranian journal of pediatrics2014
Synbiotics in Children with Cow's Milk Allergy: A Randomized Controlled Trial.
Article in Iranian journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Pooled it
- Amino Acid Formula Containing Synbiotics in Infants with Cow's Milk Protein Allergy: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Probiotics for cow's milk protein allergy: a systematic review of randomized controlled trials.European journal of pediatrics · 2019Pooled it
- A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants.Pediatric research · 2018Trial
- Review
- Osteopathic Manual Therapy for Infant Colic: A Randomised Clinical Trial.Healthcare (Basel, Switzerland) · 2023Article
- Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow's Milk Protein Allergy.International journal of molecular sciences · 2023Review
- A specific synbiotic-containing amino acid-based formula in dietary management of cow's milk allergy: a randomized controlled trial.Clinical and translational allergy · 2019Article
- Probiotics as treatment for food allergies among pediatric patients: a meta-analysis.The World Allergy Organization journal · 2018Article
- Epidemiological survey of pediatric food allergy in Mashhad in Northeast Iran.Electronic physician · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCow`s milk protein allergy usually occurs in infants within the first months of life. It can affect several organs, but gastrointestinal symptoms are the most clinical symptoms observed. The most effective treatment is restricting the cow `s milk protein in mother and infant`s diet. Lactobacillus GG supplementation in infant could be effective through modulation of the immune system and the gut microflora.
methodsThirty two breastfed infants with cow`s milk protein allergy were enrolled in a double-blinded randomized controlled trial in which they received Synbiotic (n=16) or placebo (n=16) once a day for one month, simultaneously with cow`s milk protein restriction in mother and infant`s diet. Clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding and diarrhea), head circumference, body length and weight were recorded at the beginning, the end of the first and third month of study. Findings : Percentage of increment in head circumference and weight were statistically more in synbiotic group compared with placebo group at the end of the first and third month of study. There was no significant difference in resolution of clinical gastrointestinal symptoms (vomiting, colic, rectal bleeding or diarrhea) and percentage of increment in body length.
conclusionSynbiotic supplementation in infants may improve increment of head circumference and weight gain, but has no effect on resolution of clinical symptoms.
Indexed as
Identifiers
25793042PMC4359601W2156471101What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.