ArticleExperimental neurobiology2015
Ca(2+) Entry is Required for Mechanical Stimulation-induced ATP Release from Astrocyte.
Article in Experimental neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- ATP release mediated by TRPM3 enhances invasion in glioblastoma.Animal cells and systems · 2026Article
- A 3D-1D-0D multiscale model of the neuro-glial-vascular unit for synaptic and vascular dynamics in the dorsal vagal complex.Journal of mathematical biology · 2025Article
- An Improved Ratiometric FRET Biosensor with Higher Affinity for Extracellular ATP.Sensors (Basel, Switzerland) · 2025Article
- Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors.Nature neuroscience · 2025Article
- Calcium signaling in astrocytes and gliotransmitter release.Frontiers in synaptic neuroscience · 2023Review
- Fiber optical imaging of astroglial calcium signaling in the respiratory network in the working heart brainstem preparation.Frontiers in physiology · 2023Article
- A Role for Astroglial Calcium in Mammalian Sleep and Sleep Regulation.Current biology : CB · 2020Article
- Stage-Specific Transcription Factors Drive Astrogliogenesis by Remodeling Gene Regulatory Landscapes.Cell stem cell · 2018Article
- Stretch-induced CaThe Journal of physiology · 2018Article
- CaFrontiers in molecular neuroscience · 2018Article
- Astroglial CaFrontiers in cellular neuroscience · 2018Article
- Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks.Journal of neurophysiology · 2017Review
- Cell culture: complications due to mechanical release of ATP and activation of purinoceptors.Cell and tissue research · 2017Review
- Flow Shear Stress Enhances the Proliferative Potential of Cultured Radial Glial Cells Possibly Via an Activation of Mechanosensitive Calcium Channel.Experimental neurobiology · 2017Article
- Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes.Experimental neurobiology · 2017Article
- Role of ClThe Journal of physiology · 2017Article
- Activity-triggered tetrapartite neuron-glial interactions following peripheral injury.Current opinion in pharmacology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrocytes and neurons are inseparable partners in the brain. Neurotransmitters released from neurons activate corresponding G protein-coupled receptors (GPCR) expressed in astrocytes, resulting in release of gliotransmitters such as glutamate, D-serine, and ATP. These gliotransmitters in turn influence neuronal excitability and synaptic activities. Among these gliotransmitters, ATP regulates the level of network excitability and is critically involved in sleep homeostasis and astrocytic Ca(2+) oscillations. ATP is known to be released from astrocytes by Ca(2+)-dependent manner. However, the precise source of Ca(2+), whether it is Ca(2+) entry from outside of cell or from the intracellular store, is still not clear yet. Here, we performed sniffer patch to detect ATP release from astrocyte by using various stimulation. We found that ATP was not released from astrocyte when Ca(2+) was released from intracellular stores by activation of Gαq-coupled GPCR including PAR1, P2YR, and B2R. More importantly, mechanical stimulation (MS)-induced ATP release from astrocyte was eliminated when external Ca(2+) was omitted. Our results suggest that Ca(2+) entry, but not release from intracellular Ca(2+) store, is critical for MS-induced ATP release from astrocyte.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.