ArticleJournal of inflammation research2015
Role of high-mobility group box 1 in patients with acute obstructive suppurative cholangitis-induced sepsis.
Article in Journal of inflammation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Association of serum/plasma high mobility group box 1 with autoimmune diseases: A systematic review and meta-analysis.Medicine · 2018Pooled it
- Therapeutic experience of 289 elderly patients with biliary diseases.World journal of gastroenterology · 2017Trial
- Biliary HMGB1 levels and biochemical indices in the assessment of acute obstructive septic cholangitis combined with septic shock.Clinics (Sao Paulo, Brazil) · 2025Article
- Efficacy of ultrasound-guided percutaneous transhepatic biliary drainage for acute obstructive suppurative cholangitis combined with septic shock.Clinics (Sao Paulo, Brazil) · 2023Article
- The Role of HMGB1 in Invasive Candida albicans Infection.Mycopathologia · 2021Article
- Clinical Efficacy Analysis of the Combination of the Laparoscope and Preoperative or Intraoperative Duodenoscope in the Treatment of Cholecystolithiasis with Choledocholithiasis: A Retrospective Study.Journal of laparoendoscopic & advanced surgical techniques. Part A · 2019Article
- Pathophysiologic Characterization of a Novel Rabbit Model of Biliary Tract Infection-Derived Sepsis.Scientific reports · 2019Article
- [Protective effect of early intervention with lipoxin A4 on septic mice].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- Downregulation of high mobility group protein box-1 resensitizes ovarian cancer cells to carboplatin.Oncology letters · 2018Article
- Association between high mobility group box‑1 protein expression and cell death in acute pancreatitis.Molecular medicine reports · 2017Article
- Expression of scavenger receptor A in rat's liver tissue during acute obstructive cholangitis and its significance.SpringerPlus · 2016Article
- Does Infection-Induced Immune Activation Contribute to Dementia?Aging and disease · 2015Review
- Relationship between high-mobility group box 1 overexpression in ovarian cancer tissue and serum: a meta-analysis.OncoTargets and therapy · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh-mobility group box 1 (HMGB1) is a proinflammatory cytokine that plays an active role during the pathogenesis of inflammatory processes. The primary aim of this study was to detect whether HMGB1 is involved in the pathogenesis of acute obstructive suppurative cholangitis (AOSC).
methodsWe collected peripheral blood samples from 23 patients with AOSC and 23 healthy volunteers who served as normal controls. All participants were tested for HMGB1 mRNA level, HMGB1 protein, tumor necrosis factor alpha (TNF-alpha), and interleukin 10 (IL-10). HMGB1 mRNA levels were tested using real-time polymerase chain reaction. HMGB1 protein expression was measured using Western blot. TNF-alpha and IL-10 were tested using enzyme-linked immunosorbent assay.
resultsThe expression of HMGB1 mRNA and HMGB1 protein was higher in the AOSC group than in the normal controls (P<0.01), and the levels gradually decreased to normal after treatment of the disease (P<0.01). The content of TNF-alpha and IL-10 in peripheral blood of patients with AOSC was significantly higher than that of normal controls (P<0.01) but decreased to normal levels after the necessary treatment (P<0.01).
conclusionThe levels of HMGB1 mRNA and HMGB1 protein were elevated in patients with AOSC, which may play an important role in the inflammation of the bile duct and appears to be associated with the development of sepsis. This suggests the importance of monitoring HMGB1 levels in the management of AOSC-induced sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.