ArticleCryogenics
On the Effects of Thermal History on the Development and Relaxation of Thermo-Mechanical Stress in Cryopreservation.
Article in Cryogenics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Bridging the Gap in Cryopreservation: A Review of Cryoprotectant Innovation and Global Market Trends.Bioengineering (Basel, Switzerland) · 2026Review
- Thermomechanics analysis of cryopreservation by vitrification of the popliteal artery.PloS one · 2026Article
- Multi-view cryomacroscopy: A new device for study of cryopreservation by vitrification.Cryobiology · 2025Article
- Vitreous tissue cryopreservation using a blood vessel model and cryomacroscopy for scale-up studies: Observations and mathematical modeling.Cryobiology · 2024Article
- Ice formation and its elimination in cryopreservation of oocytes.Scientific reports · 2024Article
- Ice formation and its elimination in cryopreservation of oocytes.Research square · 2024Article
- Nanowarming improves survival of vitrified ovarian tissue and follicular development in a sheep model.Heliyon · 2023Article
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- Cryopreservation of tissues and organs: present, bottlenecks, and future.Frontiers in veterinary science · 2023Review
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- Thermal Analyses of Nanowarming-Assisted Recovery of the Heart From Cryopreservation by Vitrification.Journal of heat transfer · 2022Article
- Vitrification and Rewarming of Magnetic Nanoparticle-Loaded Rat Hearts.Advanced materials technologies · 2022Article
- Thermo-mechanics aspects of isochoric cryopreservation: A new modeling approach and comparison with experimental data.PloS one · 2022Article
- Analysis of crystallization during rewarming in suboptimal vitrification conditions: a semi-empirical approach.Cryobiology · 2021Article
- Mathematical modeling of surface deformation during vitrification.Cryobiology · 2021Article
- Thermomechanical stress analysis of rabbit kidney and human kidney during cryopreservation by vitrification with the application of radiofrequency heating.Cryobiology · 2021Article
- Scaling Effects on the Residual Thermomechanical Stress During Ice-Free Cooling to Storage Temperature.Journal of applied mechanics · 2020Article
- Ultrarapid Inductive Rewarming of Vitrified Biomaterials with Thin Metal Forms.Annals of biomedical engineering · 2018Article
- Analysis of polarized-light effects in glass-promoting solutions with applications to cryopreservation and organ banking.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This study investigates the effects of the thermal protocol on the development and relaxation of thermo-mechanical stress in cryopreservation by means of glass formation, also known as vitrification. The cryopreserved medium is modeled as a homogeneous viscoelastic domain, constrained within either a stiff cylindrical container or a highly compliant bag. Annealing effects during the cooling phase of the cryopreservation protocol are analyzed. Results demonstrate that an intermediate temperature-hold period can significantly reduce the maximum tensile stress, thereby decreasing the potential for structural damage. It is also demonstrated that annealing at temperatures close to glass transition significantly weakens the dependency of thermo-mechanical stress on the cooling rate. Furthermore, a slower initial rewarming rate after cryogenic storage may drastically reduce the maximum tensile stress in the material, which supports previous experimental observations on the likelihood of fracture at this stage. This study discusses the dependency of the various stress components on the storage temperature. Finally, it is demonstrated that the stiffness of the container wall can affect the location of maximum stress, with implications on the development of cryopreservation protocols.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.