Trial reportCirculation2015
Prospective randomized trial of moderately strenuous aerobic exercise after an implantable cardioverter defibrillator.
Trial report in Circulation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Anti-Arrhythmic Effects of Exercise After an Implantable Cardioverter Defibrillator (ICD)
Effects of Inspiratory Muscle and Endurance Training on Exercise Capacity, Respiratory Muscle Strength and Endurance and Quality of Life in Heart Failure Patients With Pacemaker
Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Exercise Interventions in Patients With Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy: A SYSTEMATIC REVIEW AND META-ANALYSIS.Journal of cardiopulmonary rehabilitation and prevention · 2019Pooled it
- Home-Based Cardiac Rehabilitation: A Scientific Statement From the American Association of Cardiovascular and Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology.Journal of the American College of Cardiology · 2019Guideline
- Exercise-based cardiac rehabilitation for adult patients with an implantable cardioverter defibrillator.The Cochrane database of systematic reviews · 2019Pooled it
- Interventions to promote patient utilisation of cardiac rehabilitation.The Cochrane database of systematic reviews · 2019Pooled it
- Social Determinants of Health-Related Outcomes in an Intervention Following Initial Implantable Cardioverter-Defibrillator Implantation.Journal of the American Heart Association · 2025Trial
- Heart Failure Symptoms Improve With More Intense Physical Activity.Biological research for nursing · 2025Trial
- Social cognitive intervention following an initial implantable cardioverter defibrillator: Better treatment response for secondary versus primary prevention.Pacing and clinical electrophysiology : PACE · 2020Trial
- Effect of high-intensity interval training on peak oxygen uptake, quality of life, and ventricular arrhythmias in patients with an implantable cardioverter defibrillator: a randomized controlled trial.European heart journal open · 2026Article
- Cardiac Rehabilitation in Patients with Implantable Cardioverter-Defibrillators: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and TSA.Biomedicines · 2026Review
- Cardiac rehabilitation in patients with heart failure: clinical recommendation based on a review of the evidence.Heart failure reviews · 2025Review
- The Role of Mechanical Economy and Efficiency as Key Drivers of Cardiac Rehabilitation Exercise Performance Improvement in a Patient With Heart Failure and an Implanted CRT-D: A Case Report and Literature Review.Clinical case reports · 2025Article
- Human-Centered Design to Tailor Telehealth Cardiac Rehabilitation to Diverse Populations: The MCNAIR Study.Journal of the American Heart Association · 2025Article
- Wearable Devices for Exercise Prescription and Physical Activity Monitoring in Patients with Various Cardiovascular Conditions.CJC open · 2025Review
- STEPWISE CARDIAC REHABILITATION ADJUSTMENT AFTER EXERCISE-INDUCED IMPLANTABLE CARDIOVERTER DEFIBRILLATOR SHOCK: A CASE REPORT.Journal of rehabilitation medicine. Clinical communications · 2025Article
- Psychological and behavioral dimensions in cardiac arrest survivors and their families: A state-of-the-art review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Cardiac rehabilitation for participants with implantable cardiac devices: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2024Review
- Protocol of randomized controlled trial to evaluate the effect of moderate exercise training on the functional capacity of patients with an implantable cardioverter defibrillator in a tertiary care center in South India.Journal of education and health promotion · 2024Article
- Standardised Exercise Prescription for Patients with Chronic Coronary Syndrome and/or Heart Failure: A Consensus Statement from the EXPERT Working Group.Sports medicine (Auckland, N.Z.) · 2023Article
- A survey of the implementation rate of cardiac rehabilitation for patients with heart disease undergoing device implantation in Japan.Journal of arrhythmia · 2022Article
- Comprehensive multicomponent cardiac rehabilitation in cardiac implantable electronic devices recipients: a consensus document from the European Association of Preventive Cardiology (EAPC; Secondary prevention and rehabilitation section) and European Heart Rhythm Association (EHRA).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundDespite its salutary effects on health, aerobic exercise is often avoided after receipt of an implantable cardioverter defibrillator (ICD) because of fears that exercise may provoke acute arrhythmias. We prospectively evaluated the effects of a home aerobic exercise training and maintenance program (EX) on aerobic performance, ICD shocks, and hospitalizations exclusively in ICD recipients. METHODS AND
resultsA total of 160 patients (124 men and 36 women) were randomly assigned who had an ICD for primary (43%) or secondary (57%) prevention to EX or usual care (UC). The primary outcome was peak oxygen consumption, measured with cardiopulmonary exercise testing at baseline and 8 and 24 weeks. EX consisted of 8 weeks of home walking for 1 h/d, 5 d/wk at 60% to 80% of heart rate reserve, followed by 16 weeks of maintenance home walking for 150 min/wk. Adherence to EX was determined from exercise logs, ambulatory heart rate recordings of exercise, and weekly telephone contacts. Patients assigned to UC received no exercise directives and were monitored by monthly telephone contact. Adverse events were identified by ICD interrogations, patient reports, and medical charts. ICD recipients averaged 55±12 years and mean ejection fraction of 40.6±15.7; all were taking β-blocker medications. EX significantly increased peak oxygen consumption (EX, 26.7±7.0 mL/kg per minute; UC, 23.9±6.6 mL/kg per minute; P=0.002) at 8 weeks, which persisted during maintenance exercise at 24 weeks (EX, 26.9±7.7 mL/kg per minute; UC, 23.4±6.0 mL/kg per minute; P<0.001). ICD shocks were infrequent (EX=4 versus UC=8), with no differences in hospitalizations or deaths between groups.
conclusionsPrescribed home exercise is safe and significantly improves cardiovascular performance in ICD recipients without causing shocks or hospitalizations. CLINICAL
trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00522340.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.