ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015
Infant dietary patterns and bone mass in childhood: the Generation R Study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Food Consumption, Nutrient Intake and Status during the First 1000 days of Life in the Netherlands: a Systematic Review.Nutrients · 2019Pooled it
- Dietary Patterns, Bone Mineral Density, and Risk of Fractures: A Systematic Review and Meta-Analysis.Nutrients · 2018Pooled it
- Toddler dietary patterns from the INSIGHT randomized clinical trial comparing responsive parenting versus control: A latent class analysis.Obesity (Silver Spring, Md.) · 2024Trial
- Gestational Weight Gain and Offspring Bone Mass: Different Associations in Healthy Weight Versus Overweight Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Trial
- Exploring the Role of Dairy Consumption on the Growth and Development of Canadian Children: Protocol for a Longitudinal Mixed Method Research.JMIR research protocols · 2026Article
- Development and validation of the Meiji Nutritional Profiling System for children.Frontiers in nutrition · 2025Article
- Dietary patterns and bone density among school-aged children: a cross-sectional study in China.European journal of nutrition · 2024Article
- Evaluation of the Dietary Habits of Polish and Greek University Students in the Context of the Health Benefits of Their Diets.Nutrients · 2024Article
- Lifestyle Behaviors of Childhood and Adolescence: Contributing Factors, Health Consequences, and Potential Interventions.American journal of lifestyle medicine · 2024Review
- Household dairy production, dairy intake, and anthropometric outcomes in rural Bangladesh.Food policy · 2023Article
- Article
- Article
- Associations between dietary patterns and anaemia in 6- to 23-month-old infants in central South China.BMC public health · 2021Article
- Dietary Patterns and Pediatric Bone.Current osteoporosis reports · 2021Review
- Associated factors with dietary patterns among children under 2 years of age: a study in childcare centres and homes of South Brazil.Journal of nutritional science · 2021Article
- Exclusive breast-feeding and sociodemographic characteristics are associated with dietary patterns in children aged 4-7 years.Public health nutrition · 2019Article
- Body mass but not vitamin D status is associated with bone mineral content and density in young school children in northern Sweden.Food & nutrition research · 2016Article
- Life-course approach to nutrition.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledEarly life nutrition affects peak bone mass attainment. In this prospective cohort study, children with high adherence to a "dairy and whole grains" pattern in infancy had higher bone mineral density at the age of 6 years. Although the observed effects are small, our study provides insight into mechanisms linking early nutrition to bone acquisition in childhood.
introductionNutrition in early life may affect peak bone mass attainment. Previous studies on childhood nutrition and skeletal health mainly focused on individual nutrients, which does not consider the cumulative effects of nutrients. We investigated the associations between dietary patterns in infancy and childhood bone health.
methodsThis study included 2850 children participating in a population-based prospective cohort study. Dietary information was obtained from a food frequency questionnaire at the age of 13 months. Using principal component analysis, three major dietary patterns were extracted, explaining in total 30% of the variation in dietary intake. At the age of 6 years, a total body dual-energy X-ray absorptiometry (DXA) scan was performed, and bone mineral density (BMD), bone mineral content (BMC), area-adjusted BMC (aBMC), and bone area (BA) were analyzed.
resultsHigher adherence score to a "dairy and whole grains" pattern was positively associated with BMD and aBMC, but not with BMC and BA. Accordingly, children in the highest quartile of the "dairy and whole grains" pattern had higher BMD (difference 3.98 mg/cm(2), 95% confidence interval (CI) 0.36 to 7.61) and aBMC (difference 4.96 g, 95% CI 1.27 to 8.64) than children in the lowest quartile. Stratification for vitamin D supplementation showed that the positive associations between the "dairy and whole grains" pattern and bone outcomes were only observed in children who did not receive vitamin D supplementation. A "potatoes, rice, and vegetables" and a "refined grains and confectionery" pattern were not consistently associated with bone outcomes.
conclusionsAn infant dietary pattern characterized by high intakes of dairy and cheese, whole grains, and eggs is positively associated with bone development in childhood. Further research is needed to investigate the consequences for bone health in later life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.