Evidence map›Paper›PMID 25792190›Full record

ArticleScientific reports2015

C6-ceramide nanoliposome suppresses tumor metastasis by eliciting PI3K and PKCζ tumor-suppressive activities and regulating integrin affinity modulation.

Pu Zhang, Changliang Fu, Yijuan Hu, Cheng Dong, Yang Song, Erqun Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Drug Resistance: The Role of Sphingolipid Metabolism.International journal of molecular sciences · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Targeting Sphingolipids for Cancer Therapy.Frontiers in oncology · 2021
    Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Pu Zhang1] College of Pharmaceutical Sciences, Southwest University, Chongqing, China, 400715 [2] Department of Bioengineering, Pennsylvania State University, University Park, PA, US 16801.
Changliang FuDepartment of Bioengineering, Pennsylvania State University, University Park, PA, US 16801.
Yijuan HuRollins School of Public Health, Emory University, Atlanta, GA, US 30322.
Cheng DongDepartment of Bioengineering, Pennsylvania State University, University Park, PA, US 16801.
Yang SongCollege of Pharmaceutical Sciences, Southwest University, Chongqing, China, 400715.
Erqun SongCollege of Pharmaceutical Sciences, Southwest University, Chongqing, China, 400715.
Southwest University · CNPennsylvania State University · USEmory University · US

Funding

Multiscale modeling of leukocyte-tumor cell adhesion to endothelium in shear flowR01CA125707 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI DONG, CHENG · 2007 to 2010
$933k
NCI NIH HHS CA-125707NCI NIH HHS R01 CA125707
6 · The paper itself

Abstract

Nanoliposomal formulation of C6-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute treatment (30 min) of melanoma and breast cancer cells with nanoliposomal C6-ceramide (NaL-C6) may suppress cell migration without inducing cell death. By employing a novel flow migration assay, we demonstrated that NaL-C6 decreased tumor extravasation under shear conditions. Compared with ghost nanoliposome, NaL-C6 triggered phosphorylation of PI3K and PKCζ and dephosphorylation of PKCα. Concomitantly, activated PKCζ translocated into cell membrane. siRNA knockdown or pharmacological inhibition of PKCζ or PI3K rescued NaL-C6-mediated suppression of tumor migration. By inducing dephosphorylation of paxillin, PKCζ was responsible for NaL-C6-mediated stress fiber depolymerization and focal adhesion disassembly in the metastatic tumor cells. PKCζ and PI3K regulated cell shear-resistant adhesion in a way that required integrin αvβ3 affinity modulation. In conclusion, we identified a novel role of acute nanoliposomal ceramide treatment in reducing integrin affinity and inhibiting melanoma metastasis by conferring PI3K and PKCζ tumor-suppressive activities.

Indexed as

LiposomesNanostructuresCell Line, TumorCeramidesHumansIntegrinsNeoplasm MetastasisPhosphatidylinositol 3-KinasesPhosphorylationProtein BindingProtein Kinase CProtein Kinase C zetaProtein TransportCeramidesIntegrinsLiposomesPhosphatidylinositol 3-KinasesProtein Kinase CProtein Kinase C zeta

Identifiers

PMID25792190
PMCPMC4366857
OpenAlexW2056920891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.