Evidence map›Paper›PMID 25792144›Full record

ArticleBioorganic & medicinal chemistry2015

Preparation and biological evaluation of synthetic and polymer-encapsulated congeners of the antitumor agent pactamycin: insight into functional group effects and biological activity.

Robert J Sharpe, Justin T Malinowski, Federico Sorana, J Christopher Luft, Charles J Bowerman, Joseph M DeSimone, Jeffrey S Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Strategies for the Syntheses of Pactamycin and Jogyamycin.Angewandte Chemie (International ed. in English) · 2021
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert J SharpeDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States.
Justin T MalinowskiDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States.
Federico SoranaDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States.
J Christopher LuftDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States; Department of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States.
Charles J BowermanDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States.
Joseph M DeSimoneDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States; Department of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States; Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695-8613, United States; Carolina Center of Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States; Institute for Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States; Institute for Advanced Materials, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States; Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY 10065-9321, United States.
Jeffrey S JohnsonDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, United States. Electronic address: jsj@unc.edu.

Funding

Asymmetric Synthesis of Bioactive Natural ProductsR01GM084927 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOHNSON, JEFFREY S · 2009 to 2016
$2.2M
NIGMS NIH HHS R01 GM084927
6 · The paper itself

Abstract

The synthesis and biological analysis of a number of novel congeners of the aminocyclopentitol pactamycin is described. Specific attention was paid to the preparation of derivatives at crucial synthetic branch points of the parent structure, and biological assays revealed a number of insights into the source of pactamycin's biological activity. Additionally, the encapsulation of pactamycin and select derivatives into the PRINT© nanoparticle technology was investigated as a proof-of-concept, and evidence of bioactivity modulation through nanoparticle delivery is demonstrated. This work has provided heretofore unrealized access to a large number of novel compounds for further evaluation.

Indexed as

Antineoplastic AgentsCell Line, TumorDrug CarriersHumansNanoparticlesNeoplasmsPactamycinAntineoplastic AgentsDrug CarriersPactamycinNanoparticlesPactamycinStructural derivatizationStructure activity relationships

Identifiers

PMID25792144
PMCPMC4380168

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.