Evidence map›Paper›PMID 25791874›Full record

ArticleBritish journal of cancer2015

Human papillomavirus DNA in men who have sex with men: type-specific prevalence, risk factors and implications for vaccination strategies.

E M King, R Gilson, S Beddows, K Soldan, K Panwar, C Young, P Prah, M Jit, W J Edmunds, P Sonnenberg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Prevalence and Risk Factors of Human Papillomavirus in Male Patients: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2018
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  15. The Politics of LGBT+ Health Inequality: Conclusions from a UK Scoping Review.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

E M KingResearch Department of Infection and Population Health, University College London, London WC1E 6JB, UK.
R Gilson1] Research Department of Infection and Population Health, University College London, London WC1E 6JB, UK [2] The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London WC1E 6JB, UK.
S BeddowsVirus Reference Department, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
K SoldanHIV/STI Department, Centre for Communicable Disease Surveillance and Control (CIDSC), Public Health England, 61 Colindale Avenue London, NW9 5EQ, UK.
K PanwarVirus Reference Department, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
C Young1] Research Department of Infection and Population Health, University College London, London WC1E 6JB, UK [2] The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London WC1E 6JB, UK.
P PrahResearch Department of Infection and Population Health, University College London, London WC1E 6JB, UK.
M Jit1] Modelling and Economics Unit, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK [2] Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
W J EdmundsDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
P SonnenbergResearch Department of Infection and Population Health, University College London, London WC1E 6JB, UK.
Public Health England · GBUniversity College London · GBMortimer Market Centre · GBUniversity of London · GB

Funding

Medical Research Council G0701757
6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) vaccination of girls will have relatively little effect on HPV-related disease in men who have sex with men (MSM). We determined HPV prevalence and risk factors in MSM to inform the potential effectiveness of vaccinating MSM.

methodsCross-sectional study of 522 MSM aged 18-40 attending a London sexual health clinic who completed a computer-assisted self-interview. Urine and two swabs (anal and penile/scrotal/perianal) were collected and tested using an in-house Luminex-based HPV genotyping system.

resultsPrevalence of DNA of the vaccine-preventable HPV types in ano-genital specimens of men was 87/511 (17.0%), 166/511 (32.5%) and 232/511 (45.4%) for the bivalent (HPV16/18), quadrivalent (HPV6/11/16/18) and nonavalent (HPV6/11/16/18/31/33/45/52/58) vaccine types, respectively. A total of 25.1% had one of the quadrivalent types, and 7.4% had 2+ types. Median age at first anal sex was 19 (IQR 17-23) and at first clinic attendance was 24 (IQR 20-27). The increase in the odds of any HPV infection per year of age was 4.7% (95% CI 1.2-8.4).

conclusionsOn the basis of the current infection status, most MSM, even among a high-risk population attending a sexual health clinic, are not currently infected with the vaccine-type HPV. A targeted vaccination strategy for MSM in the UK could have substantial benefits.

Indexed as

VaccinationAdolescentAdultCross-Sectional StudiesFollow-Up StudiesHealth BehaviorHomosexuality, MaleHuman Papillomavirus DNA TestsHumansLondonMalePapillomaviridaePapillomavirus InfectionsPapillomavirus VaccinesPrevalencePrognosisPapillomavirus Vaccines

Identifiers

PMID25791874
PMCPMC4453685
OpenAlexW2012025410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.