ReviewNeuroImage2015
Miniaturized optical neuroimaging in unrestrained animals.
Review in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Tetherless miniaturized point detector device for monitoring cortical surface hemodynamics in mice.Journal of biomedical optics · 2025Article
- Distinguishing motion artifacts during optical fiber-basedNeurophotonics · 2024Article
- Astrocytes: new evidence, new models, new roles.Biophysical reviews · 2023Review
- Imaging the brain in action: a motorized optical rotary joint for wide field fibroscopy in freely moving animals.Neurophotonics · 2023Article
- Head-mounted optical imaging and optogenetic stimulation system for use in behaving primates.Cell reports methods · 2022Article
- Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice.Journal of biomedical optics · 2022Article
- Naturalistic neuroscience and virtual reality.Frontiers in systems neuroscience · 2022Review
- Fiber photometry for monitoring cerebral oxygen saturation in freely-moving rodents.Biomedical optics express · 2020Article
- A miniature multi-contrast microscope for functional imaging in freely behaving animals.Nature communications · 2019Article
- Benchmarking miniaturized microscopy against two-photon calcium imaging using single-cell orientation tuning in mouse visual cortex.PloS one · 2019Article
- Fast confocal fluorescence imaging in freely behaving mice.Scientific reports · 2018Article
- Two-photon probes for in vivo multicolor microscopy of the structure and signals of brain cells.Brain structure & function · 2018Review
- Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Transcranial Functional Ultrasound Imaging in Freely Moving Awake Mice and Anesthetized Young Rats without Contrast Agent.Ultrasound in medicine & biology · 2017Article
- Article
- Imaging brain activity during seizures in freely behaving rats using a miniature multi-modal imaging system.Biomedical optics express · 2016Article
- "Optical communication with brain cells by means of an implanted duplex micro-device with optogenetics and Ca(2+) fluoroimaging".Scientific reports · 2016Article
- Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy; cause and effect?Molecular painArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The confluence of technological advances in optics, miniaturized electronic components and the availability of ever increasing and affordable computational power have ushered in a new era in functional neuroimaging, namely, an era in which neuroimaging of cortical function in unrestrained and unanesthetized rodents has become a reality. Traditional optical neuroimaging required animals to be anesthetized and restrained. This greatly limited the kinds of experiments that could be performed in vivo. Now one can assess blood flow and oxygenation changes resulting from functional activity and image functional response in disease models such as stroke and seizure, and even conduct long-term imaging of tumor physiology, all without the confounding effects of anesthetics or animal restraints. These advances are shedding new light on mammalian brain organization and function, and helping to elucidate loss of this organization or 'dysfunction' in a wide array of central nervous system disease models. In this review, we highlight recent advances in the fabrication, characterization and application of miniaturized head-mounted optical neuroimaging systems pioneered by innovative investigators from a wide array of disciplines. We broadly classify these systems into those based on exogenous contrast agents, such as single- and two-photon microscopy systems; and those based on endogenous contrast mechanisms, such as multispectral or laser speckle contrast imaging systems. Finally, we conclude with a discussion of the strengths and weaknesses of these approaches along with a perspective on the future of this exciting new frontier in neuroimaging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.