Evidence map›Paper›PMID 25791635›Full record

SynthesisAnnals of oncology : official journal of the European Society for Medical Oncology2015

Anthropometric factors and endometrial cancer risk: a systematic review and dose-response meta-analysis of prospective studies.

D Aune, D A Navarro Rosenblatt, D S M Chan, S Vingeliene, L Abar, A R Vieira, D C Greenwood, E V Bandera, T Norat

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Annals of oncology : official journal of the European Society for Medical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07462663 (SHAPE-ENDO), which is not on this map. Cited by 158 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 26 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07462663 phase4not yet recruitingstarted 2027, after this paper: background citation

SHAPE-ENDO (Strategic Hormonal Approach & Prehabilitation in Endometrial Cancer): An Open-Label, Pilot Randomized Clinical Trial Comparing Standard Immediate Surgery Versus a Multimodal Metabolic Optimization and Prehabilitation Strategy Before Surgery in Patients With Atypical Endometrial Hyperplasia or Low-Risk Endometrioid Endometrial Cancer and BMI ≥40 kg/m²

Ran2027Enrolled80Registered outcomes34Posted comparisons0ConditionsAtypical Endometrial Hyperplasia, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I, BMI>40, Endometrial CancerArmsDietetic-Nutritional intervention, Endometrial Biopsy With or Without Hysteroscopy, GLP-1 receptor agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins
PMID 33755728PMID 33667417PMID 36216945PMID 29266019PMID 17096437PMID 23021687PMID 27654262PMID 27901412PMID 30193337PMID 33397713PMID 34238643PMID 35314087other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 26 syntheses or guidelines pooled it, 272 citations in OpenAlex.

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  4. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
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98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

D AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway d.aune@imperial.ac.uk.
D A Navarro RosenblattDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
D S M ChanDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
S VingelieneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
L AbarDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
A R VieiraDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
D C GreenwoodBiostatistics Unit, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK.
E V BanderaRutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick Rutgers School of Public Health, Piscataway, USA.
T NoratDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
Imperial College London · GBNorwegian University of Science and Technology · NORutgers, The State University of New Jersey · USUniversity of Leeds · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGreater body mass index (BMI) has been convincingly related to increased endometrial cancer risk, however, whether adiposity earlier in life or abdominal fatness is an independent risk factor and whether weight gain or greater height increases the risk is not clear.

methodsAs part of the Continuous Update Project of the World Cancer Research Fund International, we conducted a systematic review and meta-analysis of prospective studies of the association between anthropometric measures and endometrial cancer risk and searched PubMed and several other databases up to February 2015. Summary relative risks (RRs) were calculated using a random-effects model.

resultsThirty prospective studies of BMI and endometrial cancer risk with 22 320 cases among 6 445 402 participants were included. The summary RR for a 5-unit increment was 1.54 [95% confidence interval (CI) 1.47-1.61, I(2) = 81%]. Although the test for non-linearity was significant, Pnon-linearity < 0.0001, and the curve was steeper within the overweight and obese BMI ranges, there was evidence of increased risk even within the high normal BMI range. The summary RR was 1.45 (95% CI 1.28-1.64, I(2) = 76%) per 5 BMI units for BMI in young adulthood, 1.18 (95% CI 1.14-1.23, I(2) = 67%) per 5 kg increase of weight, and 1.16 (95% CI 1.12-1.20, I(2) = 51%) per 5 kg of weight gained between young adulthood and study baseline, 1.27 (95% CI 1.17-1.39, I(2) = 71%) per 10 cm increase in waist circumference, 1.21 (95% CI 1.13-1.29, I(2) = 0%) per 0.1-unit increment in waist-to-hip ratio and 1.30 (95% CI 1.19-1.41, I(2) = 0%) per 10-cm increase in hips circumference. The summary RR was 1.15 (95% CI 1.09-1.22, I(2) = 61%) for a 10-cm increase in height.

conclusionsAll measures of adiposity were associated with increased risk of endometrial cancer, and in addition increasing height was associated with increased risk.

Indexed as

Waist CircumferenceWaist-Hip RatioAnthropometryBody Mass IndexEndometrial NeoplasmsFemaleHumansObesityObesity, AbdominalOverweightRisk FactorsSeverity of Illness IndexTime Factorsbody mass indexendometrial cancerheightmeta-analysiswaist circumferencewaist-to-hip ratio

Identifiers

PMID25791635
OpenAlexW2140383751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.