ArticleJournal of materials science. Materials in medicine2015
In situ forming hydrogel composed of hyaluronate and polygalacturonic acid for prevention of peridural fibrosis.
Article in Journal of materials science. Materials in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Hyaluronic Acid in Spinal Disorders: A Narrative Review of Hot Spots and Research Perspectives.Iranian journal of medical sciences · 2026Review
- Progress in Polysaccharide-Based Hydrogels for Preventing Postoperative Adhesions: A Review.Gels (Basel, Switzerland) · 2025Review
- Docosahexaenoic Acid-Infused Core-Shell Fibrous Membranes for Prevention of Epidural Adhesions.International journal of molecular sciences · 2024Article
- Gallic acid-grafted chitosan antibacterial hydrogel incorporated with polydopamine-modified hydroxyapatite for enhancing bone healing.Frontiers in bioengineering and biotechnology · 2023Article
- Materials for Dentoalveolar Bioprinting: Current State of the Art.Biomedicines · 2021Review
- Thermosensitive Polyester Hydrogel for Application of Immunosuppressive Drug Delivery System in Skin Allograft.Gels (Basel, Switzerland) · 2021Article
- Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGENeural plasticity · 2021Article
- Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy.Journal of orthopaedic translation · 2018Review
- Functional compressive mechanics and tissue biocompatibility of an injectable SF/PU hydrogel for nucleus pulposus replacement.Scientific reports · 2017Article
- Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study.Clinical, cosmetic and investigational dermatology · 2017Article
- Crosslinking method of hyaluronic-based hydrogel for biomedical applications.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid-based hydrogels can reduce postoperative adhesion. However, the long-term application of hyaluronic acid is limited by tissue mediated enzymatic degradation. To overcome this limitation, we developed a polygalacturonic acid and hyaluronate composite hydrogel by Schiff's base crosslinking reaction. The polygalacturonic acid and hyaluronate composite hydrogels had short gelation time (less than 15 s) and degraded by less than 50 % in the presence of hyaluronidase for 7 days. Cell adhesion and migration assays showed polygalacturonic acid and hyaluronate composite hydrogels prevented fibroblasts from adhesion and infiltration into the hydrogels. Compared to hyaluronate hydrogels and commercial Medishield™ gels, polygalacturonic acid and hyaluronate composite hydrogel was not totally degraded in vivo after 4 weeks. In the rat laminectomy model, polygalacturonic acid and hyaluronate composite hydrogel also had better adhesion grade and smaller mean area of fibrous tissue formation over the saline control and hyaluronate hydrogel groups. Polygalacturonic acid and hyaluronate composite hydrogel is a system that can be easy to use due to its in situ cross-linkable property and potentially promising for adhesion prevention in spine surgeries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.