Evidence map›Paper›PMID 25791402›Full record

ArticleThe Journal of urology2015

Course and Moderators of Hot Flash Interference during Androgen Deprivation Therapy for Prostate Cancer: A Matched Comparison.

Brian D Gonzalez, Heather S L Jim, Kristine A Donovan, Brent J Small, Steve K Sutton, Jong Park, Hui-Yi Lin, Philippe E Spiess, Mayer N Fishman, Paul B Jacobsen

Open access · greenAbstract readComparative Study

PubMed Full text at PMC Publisher

In one paragraph

Article in The Journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it

0cells of the map it votes in

12citing papers in PubMed, 1 pooled it

2.0field-weighted citation impact, top 13% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

Treatment of Hot Flashes in Men With Prostate Cancer Undergoing Androgen Deprivation Therapy.The Prostate · 2026
Pooled it
Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme.Lancet (London, England) · 2021
Trial
Risk Factors for Hot Flashes Associated with Androgen Deprivation Therapy in Japanese Patients with Prostate Cancer.JMA journal · 2026
Article
Burden of Treatment-Induced Vasomotor Symptoms in Men With Prostate Cancer on Androgen-Deprivation Therapy: A Systematic Literature Review.Prostate cancer · 2026
Review
Feasibility of a novel wearable thermal device for management of bothersome hot flashes in patients with prostate cancer.Prostate cancer and prostatic diseases · 2024
Article
A 2-year prospective analysis of insomnia as a mediator of the relationship between androgen deprivation therapy and perceived cognitive function in men with prostate cancer.Cancer · 2021
Article
Integration of Patient Reported Outcomes in Drug Development in Genitourinary Cancers.Current oncology reports · 2020
Review
Evaluating the prevalence and predictive factors of vasomotor and psychological symptoms in prostate cancer patients receiving hormonal therapy: Results from a single institution experience.Clinical and translational radiation oncology · 2018
Article
Sleep disturbance in men receiving androgen deprivation therapy for prostate cancer: The role of hot flashes and nocturia.Cancer · 2018
Article
Development and Initial Validation of the Novel Scale for Assessing Quality of Life of Prostate Cancer Patients Receiving Androgen Deprivation Therapy.Chinese medical journal · 2017
Article
Clinical significance of androgen secretion disorders in men with a malignancy.Medical oncology (Northwood, London, England) · 2017
Review
Characteristics and predictors of fatigue among men receiving androgen deprivation therapy for prostate cancer: a controlled comparison.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Brian D GonzalezHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Heather S L JimHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Kristine A DonovanHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Brent J SmallHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Steve K SuttonHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Jong ParkHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Hui-Yi LinHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Philippe E SpiessHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Mayer N FishmanHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida.

Paul B JacobsenHealth Outcomes and Behavior Program, Moffitt Cancer Center, Tampa, Florida; Supportive Care Medicine, Moffitt Cancer Center, Tampa, Florida; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, Florida; Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida; Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida; School of Aging Studies, University of South Florida, Tampa, Florida. Electronic address: Paul.Jacobsen@Moffitt.org.

Moffitt Cancer Center · US

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026

$93.5M

Behavioral Oncology Education & Career DevelopmentR25CA090314 · NCI · H. LEE MOFFITT CANCER CTR &RES INST · PI BRANDON, THOMAS H · 2003 to 2018

$4.0M

Integrative Molecular Epidemiology WorkshopR25CA174664 · NCI · AMERICAN ASSOCIATION FOR CANCER RESEARCH · PI Shelley S Tworoger · 2013 to 2026

$2.8M

LHRH Agonist Therapy and Cognitive Functioning in Men with Prostate CancerR01CA132803 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI JACOBSEN, PAUL B · 2008 to 2011

$2.0M

NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA132803NCI NIH HHS R01CA132803NCI NIH HHS R25 CA090314NCI NIH HHS R25CA090314NCI NIH HHS R25 CA174664

6 · The paper itself

Abstract

purposeMany men receiving androgen deprivation therapy for prostate cancer experience hot flashes. This study aimed to describe the course of hot flash interference with time in androgen deprivation therapy recipients relative to matched prostate cancer and cancer-free controls from before the start of androgen deprivation therapy to 12 months later. We also examined demographic, clinical and genetic predictors of the impact of androgen deprivation therapy on hot flash interference. MATERIALS AND

methodsThree groups were examined, including 60 patients with prostate cancer recruited before or within 21 days of starting androgen deprivation therapy, 83 age and education matched patients with prostate cancer treated with prostatectomy only, and 86 age and education matched men with no history of cancer. Participants provided blood samples and completed the Hot Flash Related Daily Interference Scale at baseline as well as 6 and 12 months later.

resultsAndrogen deprivation therapy recipients reported increasing hot flash interference with time relative to controls (p <0.001). Group differences were evident at 6 and 12 months (all p <0.001) with androgen deprivation therapy recipients reporting greater hot flash interference than controls. Several genetic polymorphisms were found to predict greater increases in hot flash interference (all p <0.01), including polymorphisms on genes associated with vasoconstriction, immune function, neurotransmission and circadian rhythms. Androgen deprivation therapy recipients who were younger and had a lower body mass index at baseline also showed greater increases in hot flash interference with time (all p ≤0.01).

conclusionsThis study, which is to our knowledge the first to prospectively examine hot flash interference in androgen deprivation therapy recipients, reveals that those with certain genetic polymorphisms, younger age and lower body mass index had greater increases in hot flash interference with time relative to controls.

Indexed as

AgedAndrogen AntagonistsHot FlashesHumansMaleProspective StudiesProstatic NeoplasmsAndrogen Antagonistsantiandrogensgeneticshot flashesprostatic neoplasmsquality of life

Identifiers

PMID25791402

DOI10.1016/j.juro.2015.03.026

PMCPMC4546512

OpenAlexW2065157711

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.