ArticleJournal of the American Academy of Child and Adolescent Psychiatry2015
Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) traits in children and clinical ADHD.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Scoping review of precision child and youth mental health research: dwelling in possibility.Frontiers in psychiatry · 2025Pooled it
- Genetic Overlap Between Schizophrenia and Developmental Psychopathology: Longitudinal and Multivariate Polygenic Risk Prediction of Common Psychiatric Traits During Development.Schizophrenia bulletin · 2017Pooled it
- A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Pooled it
- The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review.JCPP advances · 2026Article
- ADHD and intelligence polygenic scores associations with developmental dimensions in children with attention, learning and memory difficulties.European child & adolescent psychiatry · 2026Article
- Article
- Attention Deficit Hyperactivity Disorder and other neurodevelopmental traits are associated with impact on functioning among children in the general population.JCPP advances · 2025Article
- Depression and anxiety are increased in autism and ADHD: Evidence from a young adult community-based sample.JCPP advances · 2025Article
- Intergenerational transmission of genetic risk for hyperactivity and inattention. Direct genetic transmission or genetic nurture?JCPP advances · 2024Article
- Effects of an online mindfulness-based program for parents of children with attention deficit/hyperactivity disorder: a pilot, mixed methods study.Frontiers in psychiatry · 2024Article
- Co-development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood.Journal of child psychology and psychiatry, and allied disciplines · 2023Article
- Preschool development, temperament and genetic liability as early markers of childhood ADHD: A cohort study.JCPP advances · 2022Article
- Early-Life Injuries and the Development of Attention-Deficit/Hyperactivity Disorder.The Journal of clinical psychiatry · 2022Article
- Toward Precision Medicine in ADHD.Frontiers in behavioral neuroscience · 2022Review
- Mapping relationships between ADHD genetic liability, stressful life events, and ADHD symptoms in healthy adults.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2021Article
- Association of etiological factors across the extreme end and continuous variation in disordered eating in female Swedish twins.Psychological medicine · 2021Article
- Prenatal and perinatal factors associated with ADHD risk in schoolchildren: EPINED epidemiological study.European child & adolescent psychiatry · 2021Article
- Disentangling nature from nurture in examining the interplay between parent-child relationships, ADHD, and early academic attainment.Psychological medicine · 2021Article
- Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders.Biological psychiatry · 2021Review
- Exploring characteristic features of attention-deficit/hyperactivity disorder: findings from multi-modal MRI and candidate genetic data.Brain imaging and behavior · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectiveTwin studies and genome-wide complex trait analysis (GCTA) are not in agreement regarding heritability estimates for behavioral traits in children from the general population. This has sparked a debate on the possible difference in genetic architecture between behavioral traits and psychiatric disorders. In this study, we test whether polygenic risk scores associated with variation in attention-deficit/hyperactivity disorder (ADHD) trait levels in children from the general population predict ADHD diagnostic status and severity in an independent clinical sample.
methodSingle nucleotide polymorphisms (SNPs) with p < .5 from a genome-wide association study of ADHD traits in 4,546 children (mean age, 7 years 7 months) from the Avon Longitudinal Study of Parents and Children (ALSPAC; general population sample) were selected to calculate polygenic risk scores in 508 children with an ADHD diagnosis (independent clinical sample) and 5,081 control participants. Polygenic scores were tested for association with case-control status and severity of disorder in the clinical sample.
resultsIncreased polygenic score for ADHD traits predicted ADHD case-control status (odds ratio = 1.17 [95% CI = 1.08-1.28], p = .0003), higher ADHD symptom severity (β = 0.29 [95% CI = 0.04-0.54], p = 0.02), and symptom domain severity in the clinical sample.
conclusionThis study highlights the relevance of additive genetic variance in ADHD, and provides evidence that shared genetic factors contribute to both behavioral traits in the general population and psychiatric disorders at least in the case of ADHD.
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