ArticleInternational journal of cardiology2015
Whole exome sequencing identifies the TNNI3K gene as a cause of familial conduction system disease and congenital junctional ectopic tachycardia.
Abstract readCase ReportsLetter
In one paragraph
Article in International journal of cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnosis and management of very rare primary arrhythmia syndromes in children and adults: a Clinical Consensus Statement of the European Heart Rhythm Association of the ESC and the Association of Cardiovascular Nursing & Allied Professions of the ESC, endorsed by the Association for European Paediatric and Congenital Cardiology.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Guideline
- High levels of the cardiomyocyte-specific kinase Tnni3k impair zebrafish heart regeneration by driving chronic myocardial inflammation.bioRxiv : the preprint server for biology · 2026Article
- Clockwise bundle branch re-entrant ventricular tachycardia in a teenage patient as the first manifestation of dilated cardiomyopathy associated with the p.Ile512Leu TNNI3k variant: a case report.European heart journal. Case reports · 2025Article
- [Dilated cardiomyopathy and conduction disorder due toArchivos de cardiologia de Mexico · 2025Article
- A New Mechanism of Supraventricular Tachycardia: Gene Mutation.Current cardiology reviews · 2025Review
- Expression Levels of theInternational journal of molecular sciences · 2023Article
- Genetic Burden ofCirculation. Genomic and precision medicine · 2023Article
- Whole-Exome Sequencing Identifies a Novel Variant (c.1538T > C) ofFrontiers in cardiovascular medicine · 2022Article
- The Role of POPDC Proteins in Cardiac Pacemaking and Conduction.Journal of cardiovascular development and disease · 2021Review
- The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment.International journal of molecular sciences · 2021Review
- A SPRY1 domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes.Scientific reports · 2021Article
- The prevalent I686T human variant and loss-of-function mutations in the cardiomyocyte-specific kinase gene TNNI3K cause adverse contractility and concentric remodeling in mice.Human molecular genetics · 2021Article
- Identification of a nonsense mutation in TNNI3K associated with cardiac conduction disease.Journal of clinical laboratory analysis · 2020Article
- Junctional ectopic tachycardia in infants and children.Journal of arrhythmia · 2020Review
- Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency.PLoS genetics · 2019Article
- Prenatal diagnosis and management of junctional ectopic tachycardia.HeartRhythm case reports · 2017Article
- Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration.Nature genetics · 2017Article
- Ivabradine monotherapy in congenital junctional ectopic tachycardia.Annals of pediatric cardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Yanwei XiChildren's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Christina HoneywellDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Dapeng ZhangNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Jeremy SchwartzentruberMcGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada.
Chandree L BeaulieuDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Martine TetreaultMcGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
Taila HartleyDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Jennifer MartonDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Silvia M VidalDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Jacek MajewskiMcGill University and Genome Quebec Innovation Centre, Montreal, Quebec, Canada; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
L AravindNational Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Care4Rare Canada Consortium
Michael GollobToronto General Hospital, Department of Cardiology, University of Toronto, Toronto, Ontario, Canada.
Kym M BoycottChildren's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. Electronic address: kboycott@cheo.on.ca.
Robert M GowDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. Electronic address: rgow@cheo.on.ca.
Funding
Evolutionary Analysis and Comparative Genomics of Protein SuperfamiliesZIALM594244 · NLM · NATIONAL LIBRARY OF MEDICINE · PI ARAVIND, L · 2009 to 2025
$20.3MEvolutionary Analysis and Comparative Genomics of Protein SuperfamiliesZ01LM594244 · NLM · NATIONAL LIBRARY OF MEDICINE · PI IYER, ARAVIND · 2007 to 2008
$524kCIHR GPH-129346Intramural NIH HHS Z01 LM594244Intramural NIH HHS Z99 LM999999
Abstract
PubMed holds no abstract for this paper.
Indexed as
MutationChild, PreschoolDNADNA Mutational AnalysisExomeFemaleHeart Conduction SystemHumansMalePedigreeTachycardia, Ectopic JunctionalTroponin IDNATNNI1 protein, humanTroponin IExome sequencingJunctional ectopic tachycardiaTNNI3K
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.