ArticleAnnals of epidemiology2015
Response of biomarkers of inflammation and coagulation to short-term changes in central site, local, and predicted particle number concentrations.
Article in Annals of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Health effects of ultrafine particles: a systematic literature review update of epidemiological evidence.International journal of public health · 2019Pooled it
- Short-Term and Long-Term Effects of Inhaled Ultrafine Particles on Blood Markers of Cardiovascular Diseases: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Fifteen Years of Airborne ParticulatesInternational journal of molecular sciences · 2020Review
- Sex differences in the interaction of short-term particulate matter exposure and psychosocial stressors on C-reactive protein in a Puerto Rican cohort.SSM - population health · 2019Article
- Inflammation and acute traffic-related air pollution exposures among a cohort of youth with type 1 diabetes.Environment international · 2019Article
- Metabolomic assessment of exposure to near-highway ultrafine particles.Journal of exposure science & environmental epidemiology · 2019Article
- Short-and medium-term associations of particle number concentration with cardiovascular markers in a Puerto Rican cohort.Environmental research · 2018Article
- Lessons from in-home air filtration intervention trials to reduce urban ultrafine particle number concentrations.Building and environment · 2017Article
- Association of Long-Term Near-Highway Exposure to Ultrafine Particles with Cardiovascular Diseases, Diabetes and Hypertension.International journal of environmental research and public health · 2017Article
- Occupational exposures and determinants of ultrafine particle concentrations during laser hair removal procedures.Environmental health : a global access science source · 2017Article
- Aviation Emissions Impact Ambient Ultrafine Particle Concentrations in the Greater Boston Area.Environmental science & technology · 2016Article
- Association of modeled long-term personal exposure to ultrafine particles with inflammatory and coagulation biomarkers.Environment internationalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposePrevious studies have reported acute (hours-28 days) associations between ambient ultrafine particles (UFP; diameter <0.1) and biomarkers of cardiovascular health using central site data. We evaluated particle number concentration (a proxy measure for UFP) measured at a central site, a local near-highway site and predicted residential concentrations with response of biomarkers of inflammation and coagulation in a near-highway population.
methodsParticipants provided two blood samples for analysis of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α receptor II, and fibrinogen. Mixed effect models were used to evaluate the association between PNC levels on the same day, prior 2 days, and moving averages of 3 to 28 days.
resultsEstimated effects on biomarkers of a 5000 unit increase in central site PNC generally increased with longer averaging times for IL-6, hs-CRP, and fibrinogen. Effect estimates were highest for a 28-day moving average, with 91% (95% confidence interval [CI]: 9, 230) higher IL-6 levels, 74% (95% CI: -7, 220) higher hs-CRP levels, and 59% (95% CI: -13, 130) higher fibrinogen levels. We observed no clear trend between near-highway or predicted residential PNC and any of the biomarkers.
conclusionsOnly central site PNC increased blood markers of inflammation while near-highway and predicted residential values did not. We cannot fully explain this result, although differing PNC composition is a possibility. Future studies would assist in understanding these findings.
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