Observational studyRespiration; international review of thoracic diseases2015
Impacts of comorbidities on the association between arterial stiffness and obstructive sleep apnea in the elderly.
Observational study in Respiration; international review of thoracic diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The Effects of a Simulated Workday of Prolonged Sitting on Seated versus Supine Blood Pressure and Pulse Wave Velocity in Adults with Overweight/Obesity and Elevated Blood Pressure.Journal of vascular research · 2020Trial
- Association between obstructive sleep apnea hypopnea syndrome and arteriosclerosis in patients with type 2 diabetes mellitus: mediating effect of blood pressure.Frontiers in endocrinology · 2025Article
- Hypoxia-Induced Insulin Resistance Mediates the Elevated Cardiovascular Risk in Patients with Obstructive Sleep Apnea: A Comprehensive Review.Reviews in cardiovascular medicine · 2024Review
- Impact of sleep-disordered breathing on overnight changes in arterial stiffness in patients with acute heart failure.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Higher Hospital Frailty Risk Score Is an Independent Predictor of In-Hospital Mortality in Hospitalized Older Adults with Obstructive Sleep Apnea.Geriatrics (Basel, Switzerland) · 2022Article
- Sleep apnoea in the elderly: a great challenge for the future.The European respiratory journal · 2022Review
- Characteristics of hypertension and arterial stiffness in obstructive sleep apnea: A Scandinavian experience from a prospective study of 6408 normotensive and hypertensive patients.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Hypertension is the crucial link between obstructive sleep apnea and arterial stiffness.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Targeting subclinical organ damage in obstructive sleep apnea: a narrative review.Journal of human hypertension · 2021Review
- The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome.Journal of neuroinflammation · 2020Review
- Evaluation of the calculation formulas of the cardio-ankle vascular index used in the Japanese apparatus.Vascular health and risk management · 2019Article
- Brachial-ankle pulse wave velocity, cardio-ankle vascular index, and prognosis.Vascular health and risk management · 2018Review
- Modest Improvement of Untreated Severe Sleep-Disordered Breathing in the Middle-Aged and Elderly.Psychiatry investigation · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundAlthough the impact of obstructive sleep apnea (OSA) on cardiovascular risk is reasonably well established in middle-aged patients, the debate persists as to whether OSA also increases this risk in the elderly. Arterial stiffness has been used as an early independent predictor of cardiovascular risk. STUDY
objectivesWe sought to determine whether OSA has significant effects on the arterial stiffness in the elderly population and evaluate the impact of comorbidities on the association between arterial stiffness and OSA.
methodsWe performed a cross-sectional study in a university hospital. Elderly participants (≥60 years) were invited to participate in our study between November 2010 and January 2013. OSA was diagnosed using gold standard polysomnography and arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV), cardio-ankle vascular index (CAVI) and central systolic and diastolic blood pressure (cSBP and cDBP). The high-sensitivity C-reactive protein (hs-CRP) level was also measured.
resultsWe found no significant association between the severity of OSA and the arterial stiffness-related parameters cSBP, cDBP, baPWV, CAVI and hs-CRP. However, in patients with no comorbid medical conditions or use of medications (n = 101), we showed a modest association between OSA and arterial stiffness-related parameters and hs-CRP.
conclusionWe conclude that OSA is associated with increased arterial stiffness in an otherwise healthy elderly population, although the association was obviated by comorbidities and medications perhaps due to ceiling effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.