Evidence map›Paper›PMID 25790396›Full record

ArticleAmerican journal of public health2015

Association between assisted reproductive technology conception and autism in California, 1997-2007.

Christine Fountain, Yujia Zhang, Dmitry M Kissin, Laura A Schieve, Denise J Jamieson, Catherine Rice, Peter Bearman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of public health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
12.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Assisted Reproductive Technology Surveillance - United States, 2018.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Assisted Reproductive Technology Surveillance - United States, 2017.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Assisted Reproductive Technology Surveillance - United States, 2016.Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C. : 2002) · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Christine FountainChristine Fountain is with the Department of Sociology and Anthropology, Fordham University, New York, NY. Yujia Zhang, Dmitry M. Kissin, and Denise J. Jamieson are with the National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA. Laura A. Schieve and Catherine Rice are with the National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention. Peter Bearman is with the Interdisciplinary Center for Innovative Theory and Empirics, Columbia University, New York.
Yujia Zhang
Dmitry M Kissin
Laura A Schieve
Denise J Jamieson
Catherine Rice
Peter Bearman
National Center on Birth Defects and Developmental Disabilities · US

Funding

Social Determinants of the Autism EpidemicDP1OD003635 · OD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BEARMAN, PETER SHAWN · 2007 to 2011
$4.0M
Assisted Reproductive Technologies and Increased Autism RiskR21MH096122 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BEARMAN, PETER SHAWN · 2012 to 2013
$392k
NIH HHS 1 DP1 OD003635-01NIH HHS DP1 OD003635NIMH NIH HHS R21 MH096122NIMH NIH HHS R21MH096122
6 · The paper itself

Abstract

objectivesWe assessed the association between assisted reproductive technology (ART) and diagnosed autistic disorder in a population-based sample of California births.

methodsWe performed an observational cohort study using linked records from the California Birth Master Files for 1997 through 2007, the California Department of Developmental Services autism caseload for 1997 through 2011, and the Centers for Disease Control and Prevention's National ART Surveillance System for live births in 1997 through 2007. Participants were all 5 926 251 live births, including 48 865 ART-originated infants and 32 922 cases of autism diagnosed by the Department of Developmental Services. We compared births originated using ART with births originated without ART for incidence of autism.

resultsIn the full population, the incidence of diagnosed autism was twice as high for ART as non-ART births. The association was diminished by excluding mothers unlikely to use ART; adjustment for demographic and adverse prenatal and perinatal outcomes reduced the association substantially, although statistical significance persisted for mothers aged 20 to 34 years.

conclusionsThe association between ART and autism is primarily explained by adverse prenatal and perinatal outcomes and multiple births.

Indexed as

AdultAge FactorsAutistic DisorderCaliforniaFemaleGestational AgeHumansIncidenceMultiple Birth OffspringPregnancyPregnancy OutcomeReproductive Techniques, AssistedSocioeconomic FactorsUnited States

Identifiers

PMID25790396
PMCPMC4386543
OpenAlexW2099430341

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.