ArticlePloS one2015
Clinical features of autoimmune autonomic ganglionopathy and the detection of subunit-specific autoantibodies to the ganglionic acetylcholine receptor in Japanese patients.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Novel Approaches to Treatment of Immune-Mediated Chronic Intestinal Pseudo-Obstruction.Neurology(R) neuroimmunology & neuroinflammation · 2025Pooled it
- Pediatric Cardiac Arrest Secondary to Guillain-Barré Syndrome-Induced Dysautonomia.Children (Basel, Switzerland) · 2025Article
- Immune Checkpoint Inhibitor-Related Dysautonomia in Merkel Cell Carcinoma: A Case Report.Cancer reports (Hoboken, N.J.) · 2025Review
- The Presence of Ganglionic Acetylcholine Receptor Antibodies in Sera from Patients with Functional Gastrointestinal Disorders: A Preliminary Study.Journal of personalized medicine · 2024Article
- Autoimmune Autonomic Neuropathy: From Pathogenesis to Diagnosis.International journal of molecular sciences · 2024Review
- [Neuropathic pain as a symptom in autonomic neuropathies and other rare diseases : Small fiber neuropathy: its recognition, diagnosis, and treatment].Schmerz (Berlin, Germany) · 2024Review
- Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders.Frontiers in immunology · 2024Article
- A case of relapsed gAChR-positive autoimmune autonomic ganglionopathy treated by plasma exchange and mycophenolate mofetil.Frontiers in neurology · 2024Article
- Dysautonomia associated with immune checkpoint inhibitors.Journal of neurology · 2023Review
- Anti-ganglionic acetylcholine receptor antibodies in functional neurological symptom disorder/conversion disorder.Frontiers in neurology · 2023Article
- Nonregional small fibre neuropathy in cases of autoimmune autonomic neuropathy.Journal of neurology · 2022Article
- Novel Cell-Based Assay for Alpha-3 Nicotinic Receptor Antibodies Detects Antibodies Exclusively in Autoimmune Autonomic Ganglionopathy.Neurology(R) neuroimmunology & neuroinflammation · 2022Article
- Effectiveness of treatment for 31 patients with seropositive autoimmune autonomic ganglionopathy in Japan.Therapeutic advances in neurological disorders · 2022Article
- Association between neurosarcoidosis with autonomic dysfunction and anti-ganglionic acetylcholine receptor antibodies.Journal of neurology · 2021Article
- Anti-LGI1 Encephalitis Developing Immunoglobulin Responsive Orthostatic Hypotension after Remission.Internal medicine (Tokyo, Japan) · 2021Article
- Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies.Internal medicine (Tokyo, Japan) · 2021Article
- Article
- gAChR antibodies in children and adolescents with acquired autoimmune dysautonomia in Japan.Annals of clinical and translational neurology · 2021Article
- A Flow Cytometric Assay to Detect Functional Ganglionic Acetylcholine Receptor Antibodies by Immunomodulation in Autoimmune Autonomic Ganglionopathy.Frontiers in immunology · 2021Article
- Detecting gastrointestinal manifestations in patients with systemic sclerosis using anti-gAChR antibodies.Arthritis research & therapy · 2020Article
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Authors and funding
13 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune autonomic ganglionopathy (AAG) is a rare acquired channelopathy that is characterized by pandysautonomia, in which autoantibodies to ganglionic nicotinic acetylcholine receptors (gAChR) may play a central role. Radioimmunoprecipitation (RIP) assays have been used for the sensitive detection of autoantibodies to gAChR in the serum of patients with AAG. Here, we developed luciferase immunoprecipitation systems (LIPS) to diagnose AAG based on IgGs to both the α3 and β4 gAChR subunits in patient serum. We reviewed the serological and clinical data of 50 Japanese patients who were diagnosed with AAG. With the LIPS testing, we detected anti-α3 and -β4 gAChR antibodies in 48% (24/50) of the patients. A gradual mode of onset was more common in the seropositive group than in the seronegative group. Patients with AAG frequently have orthostatic hypotension and upper and lower gastrointestinal tract symptoms, with or without anti-gAChR. The occurrence of autonomic symptoms was not significantly different between the seropositive and seronegative group, with the exception of achalasia in three patients from the seropositive group. In addition, we found a significant overrepresentation of autoimmune diseases in the seropositive group and endocrinological abnormalities as an occasional complication of AAG. Our results demonstrated that the LIPS assay was a useful novel tool for detecting autoantibodies against gAChR in patients with AAG.
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