ReviewHeadache2015
Photophobia in primary headaches.
Review in Headache, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Earmuff and eye mask in the treatment of acute primary headache in emergency department: a randomized controlled open label study.BMC emergency medicine · 2025Trial
- Altered static-dynamic interhemispheric connectivity and transcriptional features underlying lateralization in patients with migraine.The journal of headache and pain · 2026Article
- Clinical Characteristics and Patient Burden of Cluster Headache in Brazil: A Real-World Study.Advances in therapy · 2026Article
- An Overview of the Therapeutic Applications of Tinted Lenses Spectacles.Korean journal of ophthalmology : KJO · 2025Review
- Cervical Oculopathy: The Cervical Spine Etiology of Visual Symptoms and Eye Diseases-A Hypothesis Exploring Mechanisms Linking the Neck and the Eye.Diagnostics (Basel, Switzerland) · 2025Article
- Cluster Headache and Migraine Shared and Unique Insights: Neurophysiological Implications, Neuroimaging, and Biomarkers: A Comprehensive Review.Journal of clinical medicine · 2025Review
- Formoterol dynamically alters endocannabinoid tone in the periaqueductal gray inducing headache.The journal of headache and pain · 2024Article
- Visual Snow Syndrome in Patient with Migraine: Case Report and Literature Review.Journal of clinical medicine · 2024Review
- Current Knowledge about Headaches Attributed to Ischemic Stroke: Changes from Structure to Function.Brain sciences · 2023Review
- Validation of the Utah Photophobia Symptom Impact Scale (version 2) as a headache-specific photophobia assessment tool.Headache · 2023Article
- The Adaptation of 12-Item Utah Photophobia Symptom Impact Scale (UPSIS-12) in Turkish, Internal Consistency, and Reproducibility.Noro psikiyatri arsivi · 2023Article
- Debate: Are cluster headache and migraine distinct headache disorders?The journal of headache and pain · 2022Review
- The hypothalamus may mediate migraine and ictal photophobia: evidence from Granger causality analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Photophobia in headache disorders: characteristics and potential mechanisms.Journal of neurology · 2022Review
- Mechanisms and Pathways of Pain Photobiomodulation: A Narrative Review.The journal of pain · 2021Review
- Selective amplification of ipRGC signals accounts for interictal photophobia in migraine.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Automated instrument designed to determine visual photosensitivity thresholds.Biomedical optics express · 2018Article
- Photophobia: When Light Hurts, a Review.Current neurology and neuroscience reports · 2018Review
- From blast to bench: A translational mini-review of posttraumatic headache.Journal of neuroscience research · 2017Review
- Photophobia in neurologic disorders.Translational neurodegeneration · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPhotophobia is a debilitating feature of many headache disorders. OVERVIEW: Clinical and preclinical research has identified several potential pathways involved in enhanced light sensitivity. Some of these structures include trigeminal afferents in the eye, second-order neurons in the trigeminal nucleus caudalis, third-order neurons in the posterior thalamus, modulatory neurons in the hypothalamus, and fourth-order neurons in the visual and somatosensory cortices. It is unclear to what degree each site plays a role in establishing the different temporal patterns of photophobia across different disorders. Peptides such as calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide may play a role in photophobia at multiple levels of the visual and trigeminal pathways.
conclusionWhile our understanding of photophobia has greatly improved in the last decade, there are still unanswered questions. These answers will help us develop new therapies to provide relief to patients with primary headache disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.