Evidence map›Paper›PMID 25790106›Full record

ArticlePloS one2015

A novel testing model for opportunistic screening of pre-diabetes and diabetes among U.S. adults.

Yurong Zhang, Gang Hu, Lu Zhang, Rachel Mayo, Liwei Chen

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04688359 (Nurse-coordinated Follow-up Program in Primary Care), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04688359 nacompletednot on this mapstarted 2021, after this paper: background citation

Nurse-coordinated Follow-up Program in Primary Care: a Mixed-method Complex Intervention Feasibility and RCT Pilot Trial Among People at Risk for T2DM.

TypeinterventionalSponsorUniversity of AkureyriRan2021 to 2023Enrolled81ConditionsPre-diabetes, Cardiovascular Risk Factor, T2DM (Type 2 Diabetes Mellitus), Primary Health CareArmsGuided Self Determination
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  9. Iraqi Experts Consensus on the Management of Type 2 Diabetes/Prediabetes in Adults.Clinical medicine insights. Endocrinology and diabetes · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Yurong ZhangThe First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Gang HuPennington Biomedical Research Center, Baton Rouge, LA, United States of America.
Lu ZhangEpidemiology Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, United States of America.
Rachel MayoDepartment of Public Health Sciences, Clemson University, Clemson, SC, United States of America.
Liwei ChenDepartment of Public Health Sciences, Clemson University, Clemson, SC, United States of America.
Clemson University · USLouisiana State University Health Sciences Center New Orleans · USPennington Biomedical Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe study aim was to evaluate the performance of a novel simultaneous testing model, based on the Finnish Diabetes Risk Score (FINDRISC) and HbA1c, in detecting undiagnosed diabetes and pre-diabetes in Americans. RESEARCH DESIGN AND

methodsThis cross-sectional analysis included 3,886 men and women (≥ 20 years) without known diabetes from the U.S. National Health and Nutrition Examination Survey (NHANES) 2005-2010. The FINDRISC was developed based on eight variables (age, BMI, waist circumference, use of antihypertensive drug, history of high blood glucose, family history of diabetes, daily physical activity and fruit & vegetable intake). The sensitivity, specificity, and the receiver operating characteristic (ROC) curve of the testing model were calculated for undiagnosed diabetes and pre-diabetes, determined by oral glucose tolerance test (OGTT).

resultsThe prevalence of undiagnosed diabetes was 7.0% and 43.1% for pre-diabetes (27.7% for isolated impaired fasting glucose (IFG), 5.1% for impaired glucose tolerance (IGT), and 10.3% for having both IFG and IGT). The sensitivity and specificity of using the HbA1c alone was 24.2% and 99.6% for diabetes (cutoff of ≥6.5%), and 35.2% and 86.4% for pre-diabetes (cutoff of ≥5.7%). The sensitivity and specificity of using the FINDRISC alone (cutoff of ≥9) was 79.1% and 48.6% for diabetes and 60.2% and 61.4% for pre-diabetes. Using the simultaneous testing model with a combination of FINDRISC and HbA1c improved the sensitivity to 84.2% for diabetes and 74.2% for pre-diabetes. The specificity for the simultaneous testing model was 48.4% of diabetes and 53.0% for pre-diabetes.

conclusionsThis simultaneous testing model is a practical and valid tool in diabetes screening in the general U.S. population.

Indexed as

AdultAgedCross-Sectional StudiesDiabetes MellitusFemaleGlycated HemoglobinHumansMaleMass ScreeningMiddle AgedModels, StatisticalNutrition SurveysPrediabetic StatePrevalenceRisk AssessmentROC CurveGlycated Hemoglobinhemoglobin A1c protein, human

Identifiers

PMID25790106
PMCPMC4366186
OpenAlexW2025825915

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.