ArticlePloS one2015
Molecular hazard identification of non-O157 Shiga toxin-producing Escherichia coli (STEC).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Shiga Toxin-ProducingAntibiotics (Basel, Switzerland) · 2026Review
- Genotypic Profiling of Virulence and Antibiotic Resistance Genes ofInternational journal of microbiology · 2026Article
- Prevalence, identification of virulence genes, and antibiotic resistance properties of Shiga-toxin producing Escherichia coli (STEC) strains isolated from ice cream and juice in sales centers.BMC infectious diseases · 2025Article
- The Influence ofIndian journal of microbiology · 2024Article
- Hybrid genome assemblies of four Shiga toxin-producingMicrobiology resource announcements · 2023Article
- Phenotypic and genotypic characterization of Shiga toxin-producingFrontiers in microbiology · 2023Article
- Transforming Shiga toxin-producingFrontiers in microbiology · 2023Article
- Review
- Prevalence of Shiga toxin-producing Escherichia coli in Yezo sika deer (Cervus nippon yesoensis) in the Tokachi sub-prefecture of Hokkaido, Japan.The Journal of veterinary medical science · 2022Article
- Characterization of Atypical Shiga Toxin Gene Sequences and Description of Stx2j, a New Subtype.Journal of clinical microbiology · 2022Article
- Virulence factors, serogroups, and antibiotic resistance of Shiga-toxin producingIranian journal of veterinary research · 2021Article
- Genomic Investigation of Virulence Potential in Shiga ToxinFrontiers in microbiology · 2020Article
- Global and regional source attribution of Shiga toxin-producing Escherichia coli infections using analysis of outbreak surveillance data.Epidemiology and infection · 2019Article
- Cumulative acquisition of pathogenicity islands has shaped virulence potential and contributed to the emergence of LEE-negative Shiga toxin-producing Escherichia coli strains.Emerging microbes & infections · 2019Article
- Pathogenicity Islands Distribution in Non-O157 Shiga Toxin-Producing Escherichia coli (STEC).Genes · 2018Article
- Identification of Novel Biomarkers for Priority Serotypes of Shiga Toxin-ProducingFrontiers in microbiology · 2018Article
- Twenty-seven years of screening for Shiga toxin-producing Escherichia coli in a university hospital. Brussels, Belgium, 1987-2014.PloS one · 2018Article
- Serogroups, subtypes and virulence factors of shiga toxin-producingGastroenterology and hepatology from bed to bench · 2018Article
- ppGpp and cytotoxicity diversity in Shiga toxin-producing Escherichia coli (STEC) isolates.Epidemiology and infection · 2017Article
- Locus of Adhesion and Autoaggregation (LAA), a pathogenicity island present in emerging Shiga Toxin-producing Escherichia coli strains.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complexity regarding Shiga toxin-producing Escherichia coli (STEC) in food safety enforcement as well as clinical care primarily relates to the current inability of an accurate risk assessment of individual strains due to the large variety in serotype and genetic content associated with (severe) disease. In order to classify the clinical and/or epidemic potential of a STEC isolate at an early stage it is crucial to identify virulence characteristics of putative pathogens from genomic information, which is referred to as 'predictive hazard identification'. This study aimed at identifying associations between virulence factors, phylogenetic groups, isolation sources and seropathotypes. Most non-O157 STEC in the Netherlands belong to phylogroup B1 and are characterized by the presence of ehxA, iha and stx2, but absence of eae. The large variability in the number of virulence factors present among serogroups and seropathotypes demonstrated that this was merely indicative for the virulence potential. While all the virulence gene associations have been worked out, it appeared that there is no specific pattern that would unambiguously enable hazard identification for an STEC strain. However, the strong correlations between virulence factors indicate that these arrays are not a random collection but are rather specific sets. Especially the presence of eae was strongly correlated to the presence of many of the other virulence genes, including all non-LEE encoded effectors. Different stx-subtypes were associated with different virulence profiles. The factors ehxA and ureC were significantly associated with HUS-associated strains (HAS) and not correlated to the presence of eae. This indicates their candidacy as important pathogenicity markers next to eae and stx2a.
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