ArticlePloS one2015
Modelling and analysis of the feeding regimen induced entrainment of hepatocyte circadian oscillators using petri nets.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging.International journal of molecular sciences · 2024Review
- Petri Net modelling approach for analysing the behaviour ofIET systems biology · 2020Article
- Deciphering the expression dynamics of ANGPTL8 associated regulatory network in insulin resistance using formal modelling approaches.IET systems biology · 2020Article
- At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications.Frontiers in nutrition · 2019Review
- Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding.American journal of physiology. Endocrinology and metabolism · 2018Article
- Modeling and analysis of the impacts of jet lag on circadian rhythm and its role in tumor growth.PeerJ · 2018Article
- Analyzing the Behavior of Neuronal Pathways in Alzheimer's Disease Using Petri Net Modeling Approach.Frontiers in neuroinformatics · 2018Article
- Computational modeling of the cell-autonomous mammalian circadian oscillator.BMC systems biology · 2017Article
- The Synergistic Role of Light-Feeding Phase Relations on Entraining Robust Circadian Rhythms in the Periphery.Gene regulation and systems biology · 2017Article
- Fuzzy Stochastic Petri Nets for Modeling Biological Systems with Uncertain Kinetic Parameters.PloS one · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythms are certain periodic behaviours exhibited by living organism at different levels, including cellular and system-wide scales. Recent studies have found that the circadian rhythms of several peripheral organs in mammals, such as the liver, are able to entrain their clocks to received signals independent of other system level clocks, in particular when responding to signals generated during feeding. These studies have found SIRT1, PARP1, and HSF1 proteins to be the major influencers of the core CLOCKBMAL1:PER-CRY circadian clock. These entities, along with abstracted feeding induced signals were modelled collectively in this study using Petri Nets. The properties of the model show that the circadian system itself is strongly robust, and is able to continually evolve. The modelled feeding regimens suggest that the usual 3 meals/day and 2 meals/day feeding regimens are beneficial with any more or less meals/day negatively affecting the system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.