Evidence map›Paper›PMID 25789817›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2015

Racial/ethnic differences in self-reported and biologic measures of chronic stress in pregnancy.

A E B Borders, K Wolfe, S Qadir, K-Y Kim, J Holl, W Grobman

Abstract read
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
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  10. Clinical risk factors and adverse perinatal outcomes among U.S. and African-born Black women in California.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  11. Article
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  13. Article
  14. Stress-induced developmental plasticity and spontaneous preterm birth: A justice-oriented eco-evo-devo review.European journal of obstetrics & gynecology and reproductive biology: X · 2025
    Review
  15. Article
  16. Prenatal chronic inflammation and children's executive function development.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2025
    Article
  17. Article
  18. Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024
    Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A E B Borders1] Department of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, IL, USA [2] Department of Obstetrics and Gynecology, Pritzker School of Medicine, University of Chicago, Chicago, IL, USA [3] Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA [4] Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
K WolfeCenter for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
S QadirDepartment of Obstetrics and Gynecology, NorthShore University HealthSystem, Evanston, IL, USA.
K-Y KimDepartment of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
J Holl1] Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, USA [2] Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA [3] Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
W Grobman1] Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, USA [2] Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Funding

Research Career Development in Obstetrics and GynecologyK12HD050121 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Serdar E. Bulun · 2005 to 2026
$7.2M
NICHD NIH HHS 1 K12 HD050121-02NICHD NIH HHS K12 HD050121
6 · The paper itself

Abstract

objectiveRacial differences in chronic maternal stress may contribute to disparities in pregnancy outcomes. The objective is to identify racial and ethnic differences in self-reported and biologic measures of stress between non-Hispanic black (NHB) and non-Hispanic white (NHW) pregnant women. STUDY

designNHB and NHW pregnant women were enrolled before 23 weeks of gestation in this prospective cohort study. Equal numbers of women were recruited with public vs private insurance in each racial group. Self-reported stress was measured and blood samples collected in the second and third trimesters were analyzed for serum Epstein-Barr virus antibody, C-reactive protein (CRP), corticotropin-releasing hormone (CRH) and adenocorticotropic hormone (ACTH).

resultsOne hundred and twelve women were enrolled. NHW women reported more buffers against stress (P=0.04) and neighborhood satisfaction (P=0.02). NHB women reported more discrimination (P<0.001), food insecurity (P=0.04) and had significantly higher mean CRP levels and mean ACTH levels in the second and third trimesters.

conclusionSignificant differences in self-reported and biologic measures of chronic stress were identified between NHB and NHW pregnant women with similar economic characteristics. Future studies should investigate mechanisms underlying these differences and their relationship to pregnancy outcomes.

Indexed as

Pregnancy ComplicationsAdrenocorticotropic HormoneAdultAntibodies, ViralBiomarkersBlack or African AmericanCorticotropin-Releasing HormoneC-Reactive ProteinFemaleHumansPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdPregnant PeopleProspective StudiesPsychiatric Status Rating ScalesAdrenocorticotropic HormoneAntibodies, ViralBiomarkersCorticotropin-Releasing HormoneC-Reactive Protein

Identifiers

PMID25789817
PMCPMC4520762

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.