ArticlePLoS genetics2015
A genomic duplication is associated with ectopic eomesodermin expression in the embryonic chicken comb and two duplex-comb phenotypes.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Tandem duplication upstream ofiScience · 2026Article
- A review of genetic variation underlying chicken phenotypic diversity.Poultry science · 2025Review
- Skin regional specification and higher-orderScience advances · 2025Article
- Population genomic analysis identifies the complex structural variation at the fibromelanosis (FM) locus in chicken.Scientific reports · 2025Article
- Transcriptome Profiling Unveils Key Genes Regulating the Growth and Development of Yangzhou Goose Knob.International journal of molecular sciences · 2024Article
- A chromosome-level genome assembly for the Silkie chicken resolves complete sequences for key chicken metabolic, reproductive, and immunity genes.Communications biology · 2023Article
- High-density single nucleotide polymorphism markers reveal the population structure of 2 local chicken genetic resources.Poultry science · 2023Article
- Review
- Genomic and gene expression associations to morphology of a sexual ornament in the chicken.G3 (Bethesda, Md.) · 2022Article
- Molecular genetic variation of animals and plants under domestication.Proceedings of the National Academy of Sciences of the United States of America · 2022Review
- Comprehensive analysis of structural variants in chickens using PacBio sequencing.Frontiers in genetics · 2022Article
- Article
- Genome Structural Variation Landscape and Its Selection Signatures in the Fast-growing Strains of the Pacific Oyster, Crassostrea gigas.Marine biotechnology (New York, N.Y.) · 2021Article
- Brain Transcriptomics of Wild and Domestic Rabbits Suggests That Changes in Dopamine Signaling and Ciliary Function Contributed to Evolution of Tameness.Genome biology and evolution · 2020Article
- Mutations Upstream of the TBX5 and PITX1 Transcription Factor Genes Are Associated with Feathered Legs in the Domestic Chicken.Molecular biology and evolution · 2020Article
- Genome-Wide Population Genetic Analysis of Commercial, Indigenous, Game, and Wild Chickens Using 600K SNP Microarray Data.Frontiers in genetics · 2020Article
- A comparison of the association between large haplotype blocks under selection and the presence/absence of inversions.Ecology and evolution · 2019Article
- Genomic Analysis Reveals Pleiotropic Alleles at EDN3 and BMP7 Involved in Chicken Comb Color and Egg Production.Frontiers in genetics · 2019Article
- Identification of copy number variation in French dairy and beef breeds using next-generation sequencing.Genetics, selection, evolution : GSE · 2017Article
- Enhancer evolution and the origins of morphological novelty.Current opinion in genetics & development · 2017Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Duplex-comb (D) is one of three major loci affecting comb morphology in the domestic chicken. Here we show that the two Duplex-comb alleles, V-shaped (D*V) and Buttercup (D*C), are both associated with a 20 Kb tandem duplication containing several conserved putative regulatory elements located 200 Kb upstream of the eomesodermin gene (EOMES). EOMES is a T-box transcription factor that is involved in mesoderm specification during gastrulation. In D*V and D*C chicken embryos we find that EOMES is ectopically expressed in the ectoderm of the comb-developing region as compared to wild-type embryos. The confinement of the ectopic expression of EOMES to the ectoderm is in stark contrast to the causal mechanisms underlying the two other major comb loci in the chicken (Rose-comb and Pea-comb) in which the transcription factors MNR2 and SOX5 are ectopically expressed strictly in the mesenchyme. Interestingly, the causal mutations of all three major comb loci in the chicken are now known to be composed of large-scale structural genomic variants that each result in ectopic expression of transcription factors. The Duplex-comb locus also illustrates the evolution of alleles in domestic animals, which means that alleles evolve by the accumulation of two or more consecutive mutations affecting the phenotype. We do not yet know whether the V-shaped or Buttercup allele correspond to the second mutation that occurred on the haplotype of the original duplication event.
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