ArticlePloS one2015
Gene-based mapping and pathway analysis of metabolic traits in dairy cows.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Research on the Changing Characteristics of Milk Composition and Serum Metabolites Across Various Lactation Periods in Xinggao Sheep.Metabolites · 2025Article
- Exploring the Genetic Basis of Ketosis: Preliminary GWAS Findings on Beta-Hydroxybutyrate Levels in Holstein Cattle.International journal of genomics · 2025Article
- Nutrigenomic Interventions to Address Metabolic Stress and Related Disorders in Transition Cows.BioMed research international · 2022Review
- Article
- Longitudinal Phenotypes Improve Genotype Association for Hyperketonemia in Dairy Cattle.Animals : an open access journal from MDPI · 2019Article
- Genome-wide association analysis for β-hydroxybutyrate concentration in Milk in Holstein dairy cattle.BMC genetics · 2019Article
- Genome-wide association studies and genomic prediction of breeding values for calving performance and body conformation traits in Holstein cattle.Genetics, selection, evolution : GSE · 2017Article
- A Pathway-Centered Analysis of Pig Domestication and Breeding in Eurasia.G3 (Bethesda, Md.) · 2017Article
- Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract.BMC genomics · 2017Article
- Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The metabolic adaptation of dairy cows during the transition period has been studied intensively in the last decades. However, until now, only few studies have paid attention to the genetic aspects of this process. Here, we present the results of a gene-based mapping and pathway analysis with the measurements of three key metabolites, (1) non-esterified fatty acids (NEFA), (2) beta-hydroxybutyrate (BHBA) and (3) glucose, characterizing the metabolic adaptability of dairy cows before and after calving. In contrast to the conventional single-marker approach, we identify 99 significant and biologically sensible genes associated with at least one of the considered phenotypes and thus giving evidence for a genetic basis of the metabolic adaptability. Moreover, our results strongly suggest three pathways involved in the metabolism of steroids and lipids are potential candidates for the adaptive regulation of dairy cows in their early lactation. From our perspective, a closer investigation of our findings will lead to a step forward in understanding the variability in the metabolic adaptability of dairy cows in their early lactation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.