ArticlePloS one2015
Effect of extended CT perfusion acquisition time on ischemic core and penumbra volume estimation in patients with acute ischemic stroke due to a large vessel occlusion.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 32 citations in OpenAlex.
- Efficacy and safety of normobaric hyperoxia for acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials.EClinicalMedicine · 2026Article
- Segmenting Small Stroke Lesions with Novel Labeling Strategies.Machine learning in clinical neuroimaging : 7th international workshop, MLCN 2024, held in conjunction with MICCAI 2024, Marrakesh, Morocco, October 10, 2024, proceedings. MLCN (Workshop) (7th : 2024 : Marrakesh, Morocco) · 2025Article
- CT Perfusion as a Predictor of the Final Infarct Volume in Patients with Tandem Occlusion.Journal of personalized medicine · 2023Article
- Detecting CTP truncation artifacts in acute stroke imaging from the arterial input and the vascular output functions.PloS one · 2023Article
- CTP: Time for Patient-Tailored Acquisition Protocols.AJNR. American journal of neuroradiology · 2022Article
- Inferring CT perfusion parameters and uncertainties using a Bayesian approach.Quantitative imaging in medicine and surgery · 2022Article
- Effect of Conscious Sedation vs. General Anesthesia on Outcomes in Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke: A Prospective Randomized Clinical Trial.Frontiers in neurology · 2020Article
- Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes.Stroke · 2016Article
- Fast nonlinear regression method for CT brain perfusion analysis.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Intra-arterial thrombectomy: does invasive treatment lead to better outcomes than intravenous thrombolysis alone?Current cardiology reports · 2015Review
- Characteristics of Misclassified CT Perfusion Ischemic Core in Patients with Acute Ischemic Stroke.PloS one · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIt has been suggested that CT Perfusion acquisition times <60 seconds are too short to capture the complete in and out-wash of contrast in the tissue, resulting in incomplete time attenuation curves. Yet, these short acquisitions times are not uncommon in clinical practice. The purpose of this study was to investigate the occurrence of time attenuation curve truncation in 48 seconds CT Perfusion acquisition and to quantify its effect on ischemic core and penumbra estimation in patients with acute ischemic stroke due to a proximal intracranial arterial occlusion of the anterior circulation. MATERIALS AND
methodsWe analyzed CT Perfusion data with 48 seconds and extended acquisition times, assuring full time attenuation curves, of 36 patients. Time attenuation curves were classified as complete or truncated. Ischemic core and penumbra volumes resulting from both data sets were compared by median paired differences and interquartile ranges. Controlled experiments were performed using a digital CT Perfusion phantom to investigate the effect of time attenuation curve truncation on ischemic core and penumbra estimation.
resultsIn 48 seconds acquisition data, truncation was observed in 24 (67%) cases for the time attenuation curves in the ischemic core, in 2 cases for the arterial input function and in 5 cases for the venous output function. Analysis of extended data resulted in smaller ischemic cores and larger penumbras with a median difference of 13.2 (IQR: 4.3-26.0) ml (P<0.001) and; 12.4 (IQR: 4.1-25.7) ml (P<0.001), respectively. The phantom data showed increasing ischemic core overestimation with increasing tissue time attenuation curve truncation.
conclusionsTruncation is common in patients with large vessel occlusion and results in repartitioning of the area of hypoperfusion into larger ischemic core and smaller penumbra estimations. Phantom experiments confirmed that truncation results in overestimation of the ischemic core.
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