ArticleeLife2015
COMP-1 promotes competitive advantage of nematode sperm.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- SPE-55 and VHA-18 are essential for FB-MO complex assembly and transport during spermatogenesis in C. elegans.Nature communications · 2026Article
- Identification of a new allele ofmicroPublication biology · 2025Article
- Article
- O-GlcNAc transferase plays a non-catalytic role in C. elegans male fertility.PLoS genetics · 2022Article
- Inducible degradation of dosage compensation protein DPY-27 facilitates isolation of Caenorhabditis elegans males for molecular and biochemical analyses.G3 (Bethesda, Md.) · 2022Article
- Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.G3 (Bethesda, Md.) · 2021Article
- Fisher vs. the Worms: Extraordinary Sex Ratios in Nematodes and the Mechanisms that Produce Them.Cells · 2021Review
- Expression ofCells · 2021Article
- Crossing two sperm chromatin-localized mCherry transgenes into a singlemicroPublication biology · 2020Article
- Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage ineLife · 2020Article
- Natural Variation and Genetic Determinants ofGenetics · 2019Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- Measuring Sperm Guidance and Motility within the Caenorhabditis elegans Hermaphrodite Reproductive Tract.Journal of visualized experiments : JoVE · 2019Article
- Genetic Factors Influencing Sperm Competition.Frontiers in genetics · 2019Review
- Genetic Contributions to Ectopic Sperm Cell Migration inG3 (Bethesda, Md.) · 2018Article
- Rapid genome shrinkage in a self-fertile nematode reveals sperm competition proteins.Science (New York, N.Y.) · 2018Article
- Distinct unfolded protein responses mitigate or mediate effects of nonlethal deprivation of C. elegans sleep in different tissues.BMC biology · 2017Article
- Size isn't everything.eLife · 2015Article
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Abstract
Competition among sperm to fertilize oocytes is a ubiquitous feature of sexual reproduction as well as a profoundly important aspect of sexual selection. However, little is known about the cellular mechanisms sperm use to gain competitive advantage or how these mechanisms are regulated genetically. In this study, we utilize a forward genetic screen in Caenorhabditis elegans to identify a gene, comp-1, whose function is specifically required in competitive contexts. We show that comp-1 functions in sperm to modulate their migration through and localization within the reproductive tract, thereby promoting their access to oocytes. Contrary to previously described models, comp-1 mutant sperm show no defects in size or velocity, thereby defining a novel pathway for preferential usage. Our results indicate not only that sperm functional traits can influence the outcome of sperm competition, but also that these traits can be modulated in a context-dependent manner depending on the presence of competing sperm.
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