ReviewPain2015
Imaging brain mechanisms in chronic visceral pain.
Review in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Visual analysis of research hotspots and trends of external therapies in traditional Chinese medicine for chronic pain.Frontiers in medicine · 2025Pooled it
- A Randomised Controlled Trial Testing the Efficacy of an Educational Website About Functional Abdominal Pain for Children and Adolescents.European journal of pain (London, England) · 2026Trial
- Mapping the "Depression Switch" During Intraoperative Testing of Subcallosal Cingulate Deep Brain Stimulation.JAMA neurology · 2015Trial
- Activation likelihood estimation of convergent resting-state brain alterations in diarrhea-predominant IBS: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2026Article
- Review
- Brain-cancer interactions outside the CNS.Oncogene · 2026Review
- Reviewing the Peripheral and Central Mechanisms of Visceral Hypersensitivity in Intestinal Disorders.International journal of medical sciences · 2026Review
- Topological Reorganization and Resting-State Functional Connectivity in Functional Dyspepsia: Associations of Symptoms with Peripheral Cytokine Levels and Amygdala Nodal Centrality.Molecular neurobiology · 2025Article
- Research progress on the mechanisms of comorbidity between functional gastrointestinal disorders and mental disorders: A review.Medicine · 2025Review
- Cutaneous Allodynia of the Withers in Cattle: An Experimental In Vivo Neuroanatomical Preliminary Investigation of the Dichotomizing Sensory Neurons Projecting into the Reticulum and Skin of the Withers-A Case Study on Two Calves.Animals : an open access journal from MDPI · 2025Article
- Exploration of Key Brain Regions Involved in Acupuncture and Moxibustion Analgesia: An Imaging-Based Study.Journal of pain research · 2025Review
- Development and Evaluation of the Abdominal Pain Knowledge Questionnaire (A-PKQ) for Children and Their Parents.Children (Basel, Switzerland) · 2024Article
- Hyperexcitation of the glutamatergic neurons in lateral hypothalamus induced by chronic pain contributes to depression-like behavior and learning and memory impairment in male mice.Neurobiology of stress · 2024Article
- Neural circuits regulating visceral pain.Communications biology · 2024Review
- Mapping Brain Structure Variability in Chronic Pain: The Role of Widespreadness and Pain Type and Its Mediating Relationship With Suicide Attempt.Biological psychiatry · 2024Article
- Experience of early-life pain in premature infants is associated with atypical cerebellar development and later neurodevelopmental deficits.BMC medicine · 2023Article
- Clinical-functional brain connectivity signature predicts longitudinal symptom improvement after acupuncture treatment in patients with functional dyspepsia.Human brain mapping · 2023Article
- The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease.Human brain mapping · 2023Article
- The neurobiology of irritable bowel syndrome.Molecular psychiatry · 2023Review
- The Role of the Nurse in the Management of Irritable Bowel Syndrome: A Narrative Review.Translational medicine @ UniSa · 2023Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Chronic visceral pain syndromes are important clinical problems with largely unmet medical needs. Based on the common overlap with other chronic disorders of visceral or somatic pain, mood and affect, and their responsiveness to centrally targeted treatments, an important role of central nervous system in their pathophysiology is likely. A growing number of brain imaging studies in irritable bowel syndrome, functional dyspepsia, and bladder pain syndrome/interstitial cystitis has identified abnormalities in evoked brain responses, resting state activity, and connectivity, as well as in gray and white matter properties. Structural and functional alterations in brain regions of the salience, emotional arousal, and sensorimotor networks, as well as in prefrontal regions, are the most consistently reported findings. Some of these changes show moderate correlations with behavioral and clinical measures. Most recently, data-driven machine-learning approaches to larger data sets have been able to classify visceral pain syndromes from healthy control subjects. Future studies need to identify the mechanisms underlying the altered brain signatures of chronic visceral pain and identify targets for therapeutic interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.