Evidence map›Paper›PMID 25789327›Full record

ArticleJournal of diabetes research2015

Topically applied connective tissue growth factor/CCN2 improves diabetic preclinical cutaneous wound healing: potential role for CTGF in human diabetic foot ulcer healing.

F R Henshaw, P Boughton, L Lo, S V McLennan, S M Twigg

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 69 citations in OpenAlex.

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  10. Review
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  12. Topical vanadate improves tensile strength and alters collagen organisation of excisional wounds in a mouse model.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2023
    Article
  13. Wound fluid sampling methods for proteomic studies: A scoping review.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2022
    Article
  14. Review
  15. Article
  16. Diabetic Wound-Healing Science.Medicina (Kaunas, Lithuania) · 2021
    Review
  17. Article
  18. Article
  19. Evaluation of wound healing activity of ethanol extract ofJournal of traditional and complementary medicine · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

F R HenshawSydney Medical School and Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
P BoughtonDepartment of Biomedical Engineering, School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Sydney, NSW 2006, Australia.
L LoSydney Medical School and Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
S V McLennanSydney Medical School and Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia ; Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
S M TwiggSydney Medical School and Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia ; Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia.
University of Sydney · AURoyal Prince Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisTopical application of CTGF/CCN2 to rodent diabetic and control wounds was examined. In parallel research, correlation of CTGF wound fluid levels with healing rate in human diabetic foot ulcers was undertaken.

methodsFull thickness cutaneous wounds in diabetic and nondiabetic control rats were treated topically with 1 μg rhCTGF or vehicle alone, on 2 consecutive days. Wound healing rate was observed on day 14 and wound sites were examined for breaking strength and granulation tissue. In the human study across 32 subjects, serial CTGF regulation was analyzed longitudinally in postdebridement diabetic wound fluid.

resultsCTGF treated diabetic wounds had an accelerated closure rate compared with vehicle treated diabetic wounds. Healed skin withstood more strain before breaking in CTGF treated rat wounds. Granulation tissue from CTGF treatment in diabetic wounds showed collagen IV accumulation compared with nondiabetic animals. Wound α-smooth muscle actin was increased in CTGF treated diabetic wounds compared with untreated diabetic wounds, as was macrophage infiltration. Endogenous wound fluid CTGF protein rate of increase in human diabetic foot ulcers correlated positively with foot ulcer healing rate (r = 0.406; P < 0.001). CONCLUSIONS/

interpretationThese data collectively increasingly substantiate a functional role for CTGF in human diabetic foot ulcers.

Indexed as

ActinsAdministration, TopicalAgedAnimalsCollagen Type IVConnective Tissue Growth FactorDiabetes ComplicationsDiabetic FootDisease Models, AnimalFemaleHumansMacrophagesMaleMiddle AgedRatsRats, Sprague-DawleyActinsCCN2 protein, humanCollagen Type IVConnective Tissue Growth FactorRecombinant Proteins

Identifiers

PMID25789327
PMCPMC4348590
OpenAlexW3148234391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.