Evidence map›Paper›PMID 25789314›Full record

ArticleBioMed research international2015

Altered interhemispheric functional coordination in chronic tinnitus patients.

Yu-Chen Chen, Wenqing Xia, Yuan Feng, Xiaowei Li, Jian Zhang, Xu Feng, Cong-Xiao Wang, Yu Cai, Jian Wang, Richard Salvi and 1 more

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In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu-Chen ChenJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China ; Center for Hearing and Deafness, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.
Wenqing XiaMedical School, Southeast University, Nanjing 210009, China ; Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yuan FengDepartment of Radiology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China.ORCID 0000-0002-5192-5121
Xiaowei LiMedical School, Southeast University, Nanjing 210009, China.
Jian ZhangJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Xu FengDepartment of Otolaryngology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Cong-Xiao WangJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Yu CaiJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Jian WangDepartment of Physiology, Southeast University, Nanjing 210009, China ; School of Human Communication Disorders, Dalhousie University, Halifax, NS, Canada B3J 1Y6.
Richard SalviCenter for Hearing and Deafness, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.ORCID 0000-0001-9061-8602
Gao-Jun TengJiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose. Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients. Materials and Methods. Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning. We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups. Results. Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus. In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus. Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex. Conclusions. These results show altered interhemispheric functional connectivity linked with specific tinnitus characteristics in chronic tinnitus patients, which may be implicated in the neuropathophysiology of tinnitus.

Indexed as

AdultBrainBrain MappingCase-Control StudiesChronic DiseaseFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedTinnitus

Identifiers

PMID25789314
PMCPMC4350869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.