Evidence map›Paper›PMID 25789301›Full record

ReviewWorld journal of clinical cases2015

Asthma and metabolic syndrome: Current knowledge and future perspectives.

Laura Serafino-Agrusa, Mario Spatafora, Nicola Scichilone

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of clinical cases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 67 citations in OpenAlex.

  1. Well-controlled asthma does not adversely affect outcomes following anterior cervical discectomy and fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  12. Association between asthma, obesity, and metabolic syndrome in adolescents and young adults.The Journal of asthma : official journal of the Association for the Care of Asthma · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Laura Serafino-AgrusaLaura Serafino-Agrusa, Mario Spatafora, Nicola Scichilone, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, 90146 Palermo, Italy.
Mario SpataforaLaura Serafino-Agrusa, Mario Spatafora, Nicola Scichilone, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, 90146 Palermo, Italy.
Nicola ScichiloneLaura Serafino-Agrusa, Mario Spatafora, Nicola Scichilone, Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, 90146 Palermo, Italy.
University of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma and obesity are epidemiologically linked; however, similar relationships are also observed with other markers of the metabolic syndrome, such as insulin resistance and dyslipidemia, which cannot be accounted for by increased body mass alone. Obesity appears to be a predisposing factor for the asthma onset, both in adults and in children. In addition, obesity could make asthma more difficult to control and to treat. Although obesity may predispose to increased Th2 inflammation or tendency to atopy, other mechanisms need to be considered, such as those mediated by hyperglycaemia, hyperinsulinemia and dyslipidemia in the context of metabolic syndrome. The mechanisms underlying the association between asthma and metabolic syndrome are yet to be determined. In the past, these two conditions were believed to occur in the same individual without any pathogenetic link. However, the improvement in asthma symptoms following weight reduction indicates a causal relationship. The interplay between these two diseases is probably due to a bidirectional interaction. The purpose of this review is to describe the current knowledge about the possible link between metabolic syndrome and asthma, and explore potential application for future studies and strategic approaches.

Indexed as

AsthmaDyslipidemiaHyperinsulinemiaMetabolic syndromeObesity

Identifiers

PMID25789301
PMCPMC4360500
OpenAlexW2069637368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.