ArticleAdvanced pharmaceutical bulletin2015
Effect of intrahippocampal administration of vitamin C and progesterone on learning in a model of multiple sclerosis in rats.
Article in Advanced pharmaceutical bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Exploration of the Role of Vitamins in Preventing Neurodegenerative Diseases: Comprehensive Review on Preclinical and Clinical Findings.Current neuropharmacology · 2025Review
- Therapeutic Potential of Combined Therapy of Vitamin A and Vitamin C in the Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats.Molecular neurobiology · 2022Article
- Antioxidant-based neuroprotective effect of dimethylsulfoxide against induced traumatic brain injury in a rats model.Frontiers in pharmacology · 2022Article
- The Role of Vitamins in Neurodegenerative Disease: An Update.Biomedicines · 2021Review
- Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and morphological alterations in rat brain.Metabolic brain disease · 2021Article
- Vitamin B12 and estradiol benzoate improve memory retrieval through activation of the hippocampal AKT, BDNF, and CREB proteins in a rat model of multiple sclerosis.Iranian journal of basic medical sciences · 2021Article
- A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis.eNeurologicalSci · 2018Review
- Preventive and therapeutic potential of ascorbic acid in neurodegenerative diseases.CNS neuroscience & therapeutics · 2017Review
- Models for Studying Myelination, Demyelination and Remyelination.Neuromolecular medicine · 2017Review
- Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to evaluate the effect of intrahippocampal injection of vitamin C and progesterone, alone or in combination, on passive avoidance learning (PAL) in multiple sclerosis.
methodsSixty- three male wistar rats were divided into nine groups (n=7) as following: control (saline), lesion, vitamin C (0.2, 1, 5 mg/kg), progesterone (0.01, 0.1, 1 µg/µl) and combination therapy. Lesion was induced by intrahippocampal injection of ethidium bromide. In combination therapy, animals were treated with vitamin C (5 mg/kg) plus progesterone (0.01 mg/kg). Animals in experimental groups received different treatments for 7 days, and then all groups were tested for step through latency (STL).
resultsOur results showed that intrahippocampal injection of ethidium bromide destroys PAL significantly (p<0.001). Treatment with vitamin C (5mg/kg) significantly (p<0.05) improved PAL. Lower doses of progesterone did not affect latency but dose of 1 µg/µl significantly (p<0.05) increased STL. In combination therapy group STL was significantly (p<0.05) more than in the lesion group, although it was not significantly different from the vitamin C group.
conclusionBased on our results, we concluded that intrahippocampal injection of vitamin C improves memory for PAL, but progesterone alone or in combination with vitamin C had no improving effects on memory.
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