Evidence map›Paper›PMID 25789173›Full record

Observational studyPulmonary medicine2015

Higher mobility scores in patients with cystic fibrosis are associated with better lung function.

Aneesha Thobani, Jessica A Alvarez, Shaina Blair, Kaila Jackson, Eric R Gottlieb, Seth Walker, Vin Tangpricha

Registry-linked trialOpen access · goldAbstract readObservational Study
In one paragraph

Observational study in Pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02700282 (Impact of Backpack Position on Lung Function and Oxygen Consumption in School-aged Children With Cystic Fibrosis), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02700282 phase4completednot on this mapstarted 2016, after this paper: background citation

Impact of Backpack Position on Lung Function and Oxygen Consumption in School-aged Children With Cystic Fibrosis

TypeinterventionalSponsorGroupe Hospitalier du HavreRan2016 to 2016Enrolled27ConditionsCystic FibrosisArmsBackpack Carrying
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. The 2025 European Cystic Fibrosis Society position statement on physical activity assessment in cystic fibrosis.European respiratory review : an official journal of the European Respiratory Society · 2025
    Guideline
  2. Interrelationships among handgrip strength, body composition, physical activity, and quality of life in adults with cystic fibrosis: A cross-sectional study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Observational
  3. Article
  4. Article
  5. Exercise and Cystic Fibrosis.Advances in experimental medicine and biology · 2020
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aneesha ThobaniDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jessica A AlvarezDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA ; Nutrition Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA.
Shaina BlairEmory University Cystic Fibrosis Center, Atlanta, GA 30322, USA.
Kaila JacksonDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Eric R GottliebThe University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Seth WalkerDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Vin TangprichaDivision of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA ; Nutrition Health Sciences Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA ; Emory University Cystic Fibrosis Center, Atlanta, GA 30322, USA ; Atlanta VA Medical Center, Decatur, GA 30022, USA.ORCID 0000-0002-4021-5853
Emory University · USUniversity of Maryland, Baltimore · US

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
ENDOCRINOLOGY, METABOLISM, AND DIABETEST32DK007298 · NIDDK · EMORY UNIVERSITY · PI PACIFICI, ROBERTO · 1986 to 2014
$3.2M
Role of T-cells in Osteoporosis in Women Undergoing Surgical MenopauseK23AR054334 · NIAMS · EMORY UNIVERSITY · PI TANGPRICHA, VIN · 2007 to 2011
$641k
Integration of Nutritional Metabolomics with Bioenergetics in Cystic FibrosisK01DK102851 · NIDDK · EMORY UNIVERSITY · PI ALVAREZ, JESSICA ALEJANDRA · 2014 to 2018
$614k
NCATS NIH HHS UL1 TR000454NIAMS NIH HHS K23 AR054334NIDDK NIH HHS K01 DK102851NIDDK NIH HHS T32 DK007298
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine whether mobility and physical activity were associated with lung function in adults with cystic fibrosis (CF).

designThis was a prospective cohort observational study in an urban, academic, specialized care center. Participants were ambulatory, nonhospitalized adults with CF.

main outcome measuresMobility was assessed monthly by the Life-Space Assessment (LSA) questionnaire and quarterly by pedometer. Lung function was assessed by spirometry.

resultsTwenty-seven subjects participated. Subjects recorded mean pedometer steps of 20,213 ± 11,331 over three days and FEV1% predicted of 77.48% ± 22.60% over one year. The LSA score at enrollment was correlated with initial pedometer steps (r = 0.42 and P = 0.03), and mean LSA score over one year was correlated with mean number of steps (r = 0.51 and P = 0.007). LSA mobility and pedometer scores were correlated with FEV1% predicted at enrollment and throughout the study.

conclusionsMobility and physical activity measured by LSA questionnaire and pedometer are positively associated with lung function in adults with CF. This study confirms the importance of mobility and physical activity and supports the utility of a simple office-based questionnaire as a measure of mobility in adults with CF.

Indexed as

AdultCystic FibrosisExerciseFemaleForced Expiratory VolumeHumansMaleMotor ActivityProspective StudiesQuality of LifeSpirometrySurveys and QuestionnairesYoung Adult

Identifiers

PMID25789173
PMCPMC4348578
OpenAlexW2026319459

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.