ArticleMolecular autism2015
Fmrp targets or not: long, highly brain-expressed genes tend to be implicated in autism and brain disorders.
Article in Molecular autism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Contribution of autosomal rare and de novo variants to sex differences in autism.American journal of human genetics · 2025Article
- MYT1L deficiency impairs excitatory neuron trajectory during cortical development.Nature communications · 2024Article
- Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease.Biology of sex differences · 2024Article
- Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease.medRxiv : the preprint server for health sciences · 2023Article
- The Vulnerability of the Developing Brain: Analysis of Highly Expressed Genes in Infant C57BL/6 Mouse Hippocampus in Relation to Phenotypic Annotation Derived From Mutational Studies.Bioinformatics and biology insights · 2022Article
- Article
- Genetic association of FMRP targets with psychiatric disorders.Molecular psychiatry · 2021Article
- Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Massively Parallel Reporter Assays: Defining Functional Psychiatric Genetic Variants Across Biological Contexts.Biological psychiatry · 2021Review
- CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a Role in Destabilizing Synaptic Gene mRNAs through Interaction with 3' UTR Elements.Cell reports · 2020Article
- FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability.Complex psychiatry · 2020Review
- Genetics of intellectual disability in consanguineous families.Molecular psychiatry · 2019Article
- Autism risk genes are evolutionarily ancient and maintain a unique feature landscape that echoes their function.Autism research : official journal of the International Society for Autism Research · 2019Article
- Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations.Nature communications · 2018Article
- Rare variants and de novo variants in mesial temporal lobe epilepsy with hippocampal sclerosis.Neurology. Genetics · 2018Article
- Widespread Genotype-Phenotype Correlations in Intellectual Disability.Frontiers in psychiatry · 2018Article
- Transcriptomic Analysis of Ribosome-Bound mRNA in Cortical NeuritesThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Strength of functional signature correlates with effect size in autism.Genome medicine · 2017Article
- Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat.Frontiers in aging neuroscience · 2017Article
- Quantitative Nucleotide Level Analysis of Regulation of Translation in Response to Depolarization of Cultured Neural Cells.Frontiers in molecular neuroscience · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMany studies have demonstrated a robust statistical overlap between genes whose transcripts are reported as Fragile X Mental Retardation Protein (Fmrp)-binding targets and genes implicated in various psychiatric disorders, including autism. However, it is not clear how to interpret this overlap as the Fmrp protein itself is not considered to be central to all instances of these conditions.
findingsWe tested whether Fmrp binding may be a proxy for some other features of these transcripts. Reviewing recent literature on the cross-linking and immunoprecipitation (CLIP)-derived targets of Fmrp in the brain, and the literature on identifying genes thought to mediate autism and other psychiatric disorders, reveals that both appear to be disproportionately made up of highly brain-expressed genes. This suggests a parsimonious explanation-that the overlap between Fmrp targets and neuropsychiatric candidate genes might be secondary to simple features such as transcript length and robust expression in the brain. Indeed, reanalyzing Fmrp high-throughput sequencing of RNAs isolated by CLIP (HITS-CLIP) data suggests that approximately 60% of CLIP tag depth can be predicted by gene expression, coding sequence length, and transcript length. Furthermore, there is a statistically significant overlap between autism candidate genes and random samples of long, highly brain-expressed genes, whether they are Fmrp targets or not.
conclusionsComparison of known Fmrp-binding targets to candidate gene lists should be informed by both of these features.
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