Evidence map›Paper›PMID 25789011›Full record

ArticleOncology letters2015

Effects of targeted phosphorylation site mutations in the DNA-PKcs phosphorylation domain on low and high LET radiation sensitivity.

Ian M Cartwright, Justin J Bell, Junko Maeda, Matthew D Genet, Ashley Romero, Yoshihiro Fujii, Akira Fujimori, Hisashi Kitamuta, Tadashi Kamada, David J Chen and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Ian M CartwrightDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Justin J BellDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Junko MaedaDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Matthew D GenetDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Ashley RomeroDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Yoshihiro FujiiDepartment of Radiological Sciences, Ibaraki Prefectural University of Health Sciences, Inashiki, Ibaraki 300-0394, Japan.
Akira FujimoriResearch Center for Charged Particle Therapy, International Open Laboratory, Inage, Chiba 263-8555, Japan.
Hisashi KitamutaResearch, Development and Support Center, National Institute of Radiological Sciences, Inage, Chiba 263-8555, Japan.
Tadashi KamadaResearch Center for Charged Particle Therapy, International Open Laboratory, Inage, Chiba 263-8555, Japan.
David J ChenDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
Takamitsu A KatoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Colorado State University · USThe Open University of Japan · JPIbaraki Prefectural University of Health Sciences · JPThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigated the effect of targeted mutations in the DNA-dependent protein kinase catalytic subunit and phosphorylation domains on the survival of cells in response to different qualities of ionizing radiation. Mutated Chinese hamster ovary V3 cells were exposed to 500 MeV/nucleon initial energy and 200 keV/μm monoenergetic Fe ions; 290 MeV/nucleon initial energy and average 50 keV/μm spread-out Bragg peak C ions; 70 MeV/nucleon initial energy and 1 keV/μm monoenergetic protons; and 0.663 MeV initial energy and 0.3 keV/μm Cs

Indexed as

DNA-protein kinase catalytic subunitheavy ionshigh linear energy transfer radiationprotons

Identifiers

PMID25789011
PMCPMC4356358
OpenAlexW2018867960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.