ArticleOncology letters2015
miR-218 inhibits the migration and invasion of glioma U87 cells through the Slit2-Robo1 pathway.
Article in Oncology letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- An intron SNP rs666088 in SLIT2 increases the risk of acute coronary syndrome in an Iranian population.BMC medical genomics · 2025Article
- Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation.BMC anesthesiology · 2021Review
- Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis.ESC heart failure · 2021Article
- LncRNA-NONHSAT024778 promote the proliferation and invasion of chordoma cell by regulating miR-1290/Robo1 axis.International journal of biological sciences · 2021Article
- The potential of Slit2 as a therapeutic target for central nervous system disorders.Expert opinion on therapeutic targets · 2020Review
- Hempseed Lignanamides Rich-Fraction: Chemical Investigation and Cytotoxicity towards U-87 Glioblastoma Cells.Molecules (Basel, Switzerland) · 2020Article
- miR‑218 functions as a tumor suppressor gene in cervical cancer.Molecular medicine reports · 2020Article
- A novel miR-7156-3p-HOXD13 axis modulates glioma progression by regulating tumor cell stemness.International journal of biological sciences · 2020Article
- Survivin is a prognostic indicator in glioblastoma and may be a target of microRNA-218.Oncology letters · 2019Article
- Slit2 Modulates the Inflammatory Phenotype of Orbit-Infiltrating Fibrocytes in Graves' Disease.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway.BMC cancer · 2018Article
- Downregulation of the long non-coding RNA taurine-upregulated gene 1 inhibits glioma cell proliferation and invasion and promotes apoptosis.Oncology letters · 2018Article
- MicroRNA-485-5p attenuates cell proliferation in glioma by directly targeting paired box 3.American journal of cancer research · 2018Article
- Suppression of microRNA-130b inhibits glioma cell proliferation and invasion, and induces apoptosis by PTEN/AKT signaling.International journal of molecular medicine · 2018Article
- Suppression of PDCD4 mediated by the long non-coding RNA HOTAIR inhibits the proliferation and invasion of glioma cells.Oncology letters · 2016Article
- MicroRNA-218 modulates activities of glioma cells by targeting HMGB1.American journal of translational research · 2016Article
- MiR-218 inhibits the tumorgenesis and proliferation of glioma cells by targeting Robo1.Cancer biomarkers : section A of Disease markers · 2016Article
- MicroRNA as potential biomarkers in Glioblastoma.Journal of neuro-oncology · 2015Review
Corrections and comments
- Retraction · 2023-09-25Concerns/Issues about Data · Duplication of/in Image · Euphemisms for Duplication · Euphemisms for Plagiarism · Objections by Third Party · Paper Mill · Plagiarism of Data · · see also: https://pubpeer.com/publications/92E9871D8E8B823F9D8FBA4B14144F
- Retracted
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malignant gliomas are the most common primary brain tumors in adults and are associated with the highest mortality rate. Glioma invasion is one of the most notable causes of the poor prognosis of this cancer. Preventing the invasive behavior of malignant glioma cells by altering effector molecules can significantly improve the prognosis of a patient. microRNAs (miRNAs) are small noncoding RNAs, ~22 nucleotides in length, that are able to function as oncogenes or tumor suppressors in human cancer. In the present study, the expression level of miRNA 218 (miR-218) was found to be markedly downregulated in glioma cell lines and human primary glioma tissues. miR-218 upregulation was found to dramatically reduce the migratory speed and invasive ability of glioma cells. Furthermore, it was demonstrated that ectopic expression of miR-218 in glioma cells resulted in the downregulation of roundabout, axon guidance receptor, homolog 1 (Robo1), upregulation of Slit homolog 2 (Slit2) and the expression of associated proteins following Robo1 knockdown by small interfering RNA. In addition, it was demonstrated that miR-218 inactivated the Slit2-Robo1 pathway through downregulating Robo1 expression by directly targeting the 3'-untranslated region (3'-UTR) of Robo1. The present results indicate that miR-218 plays important roles in preventing the invasiveness of glioma cells, and reveals a novel mechanism of miRNA-mediated direct suppression of the Slit2-Robo1 pathway in glioma.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.