ArticleAllergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology2014
Two year effects of food allergen immunotherapy on quality of life in caregivers of children with food allergies.
Article in Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Improvement in Health-Related Quality of Life in Food-Allergic Patients: A Meta-Analysis.The journal of allergy and clinical immunology. In practice · 2021Pooled it
- Anti-IgE treatment with oral immunotherapy in multifood allergic participants: a double-blind, randomised, controlled trial.The lancet. Gastroenterology & hepatology · 2018Trial
- Changing Patient Mindsets about Non-Life-Threatening Symptoms During Oral Immunotherapy: A Randomized Clinical Trial.The journal of allergy and clinical immunology. In practiceTrial
- Impact of Allergen-Specific Subcutaneous Immunotherapy on 12-Month Health-Related Quality of Life in Children and Their Parental Caregivers.Allergy, asthma & immunology research · 2026Article
- Oral Immunotherapy Should Play a Key Role in Preschool Food Allergy Management.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- Psychological Distress and Perceived Burden in Parents of Korean Children With IgE-Mediated Food Allergy.Journal of Korean medical science · 2023Article
- Children and caregiver proxy quality of life from peanut oral immunotherapy trials.Clinical and translational allergy · 2022Article
- Oral Immunotherapy in Food Allergy: A Critical Pediatric Perspective.Frontiers in pediatrics · 2022Review
- Weighing the benefits and risks of oral immunotherapy in clinical practice.Allergy and asthma proceedings · 2021Article
- The Peanut Allergy Burden Study: Impact on the quality of life of patients and caregivers.The World Allergy Organization journal · 2021Article
- Oral Immunotherapy for Food-Allergic Children: A Pro-Con Debate.Frontiers in immunology · 2021Review
- A Practical, Stepwise Approach to Peanut Oral Immunotherapy in Clinical Practice: Benefits and Risks.Journal of asthma and allergy · 2021Review
- Latest Developments in the Management of Nut Allergies.Current treatment options in allergy · 2021Review
- ICER report for peanut OIT comes up short.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- The future outlook on allergen immunotherapy in children: 2018 and beyond.Italian journal of pediatrics · 2018Review
- Parental and parent-perceived child interest in clinical trials for food allergen immunotherapy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Article
- Elimination diet and the development of multiple tree-nut allergies.Pediatric research · 2017Article
- Emerging Approaches to Food Desensitization in Children.Current allergy and asthma reports · 2017Review
- Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report.Italian journal of pediatrics · 2017Review
- Observational long-term follow-up study of rapid food oral immunotherapy with omalizumab.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFood allergy (FA) can have serious psychosocial and economic repercussions on food-allergic children and their caregivers and be associated with negative effects on their quality of life. Food allergen immunotherapy (IT) is a promising experimental therapy but can be linked to anxiety. This study investigated the effects of IT on FA-specific health-related quality of life (HRQL) over a 24 month-follow-up in caregivers of children with single and multiple food allergies. We hypothesized that characteristics such as age, asthma at baseline and respiratory allergic reactions during therapy were key characteristics that influenced HRQL scores.
methodsA validated Food Allergy Quality of Life - Parental Burden Questionnaire (FAQL-PB) was used to assess HRQL. It was randomly distributed to and filled out by caregivers of 57 food-allergic children enrolled in clinical trials of IT. The same parent answered the FABQL-PB questionnaire at baseline and for 6-month, 12- month, 18- month, and 24-month time points on IT.
resultsCaregiver HRQL improved significantly (change < - 0.5, p <0.0001) at each follow-up time point compared to baseline. The percentages of caregivers with improvement in HRQL progressively increased (92% at 24 month-follow-up time point compared to baseline). HRQL improved more in caregivers of participants older than 10 years or desensitized to more than 4 food allergens than those who were not (p <0.0001). Caregivers of participants with pre-existing asthma or dose-related respiratory allergic reactions had less improvement in HRQL than those who did not (p <0.01).
conclusionIT lead to improvement in caregiver HRQL. Certain characteristics were associated with greater improvements in caregiver HRQL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.