Evidence map›Paper›PMID 25788893›Full record

ReviewFrontiers in endocrinology2015

Mechanisms mediating environmental chemical-induced endocrine disruption in the adrenal gland.

Daniel B Martinez-Arguelles, Vassilios Papadopoulos

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Urinary di(2-ethylhexyl)phthalate metabolite ratios in obese children of South Korea.Environmental science and pollution research international · 2021
    Article
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  12. Article
  13. Review
  14. Observational
  15. Article
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  19. Prenatal Exposure to DEHP Induces Premature Reproductive Senescence in Male Mice.Toxicological sciences : an official journal of the Society of Toxicology · 2017
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daniel B Martinez-ArguellesDepartment of Medicine, Research Institute of the McGill University Health Centre, McGill University , Montreal, QC , Canada ; Department of Biochemistry, Research Institute of the McGill University Health Centre, McGill University , Montreal, QC , Canada.
Vassilios PapadopoulosDepartment of Medicine, Research Institute of the McGill University Health Centre, McGill University , Montreal, QC , Canada ; Department of Biochemistry, Research Institute of the McGill University Health Centre, McGill University , Montreal, QC , Canada ; Department of Pharmacology and Therapeutics, Research Institute of the McGill University Health Centre, McGill University , Montreal, QC , Canada.
McGill University Health Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Humans are continuously exposed to hundreds of man-made chemicals that pollute the environment in addition to multiple therapeutic drug treatments administered throughout life. Some of these chemicals, known as endocrine disruptors (EDs), mimic endogenous signals, thereby altering gene expression, influencing development, and promoting disease. Although EDs are eventually removed from the market or replaced with safer alternatives, new evidence suggests that early-life exposure leaves a fingerprint on the epigenome, which may increase the risk of disease later in life. Epigenetic changes occurring in early life in response to environmental toxicants have been shown to affect behavior, increase cancer risk, and modify the physiology of the cardiovascular system. Thus, exposure to an ED or combination of EDs may represent a first hit to the epigenome. Only limited information is available regarding the effect of ED exposure on adrenal function. The adrenal gland controls the stress response, blood pressure, and electrolyte homeostasis. This endocrine organ therefore has an important role in physiology and is a sensitive target of EDs. We review herein the effect of ED exposure on the adrenal gland with particular focus on in utero exposure to the plasticizer di(2-ethylehyl) phthalate. We discuss the challenges associated with identifying the mechanism mediating the epigenetic origins of disease and availability of biomarkers that may identify individual or population risks.

Indexed as

adrenal glandDEHPendocrine disruptorsepigeneticsinflammationperoxisome proliferator-activated receptorphthalatesreduced representation bisulfite sequencing

Identifiers

PMID25788893
PMCPMC4349159
OpenAlexW2044132862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.