Evidence map›Paper›PMID 25788889›Full record

ArticleFrontiers in psychology2015

A brief review of exercise, bipolar disorder, and mechanistic pathways.

Daniel Thomson, Alyna Turner, Sue Lauder, Margaret E Gigler, Lesley Berk, Ajeet B Singh, Julie A Pasco, Michael Berk, Louisa Sylvia

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Bipolar II disorder: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Neuroinflammation in Bipolar Depression.Frontiers in psychiatry · 2020
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Daniel ThomsonDepartment of Applied Sciences, Royal Melbourne Institute of Technology University , Bundoora, VIC, Australia.
Alyna TurnerInnovation in Mental and Physical Health and Clinical Treatment Strategic Research Centre, School of Medicine, Deakin University , Geelong, VIC, Australia ; Department of Psychiatry, University of Melbourne , Parkville, VIC, Australia ; Centre for Translational Neuroscience and Mental Health, School of Medicine and Public Health, University of Newcastle , Callaghan, NSW, Australia.
Sue LauderDepartment of Psychiatry, University of Melbourne , Parkville, VIC, Australia ; Federation University Australia , Ballarat, VIC, Australia.
Margaret E GiglerDepartment of Psychiatry, Massachusetts General Hospital , Boston, MA, USA.
Lesley BerkInnovation in Mental and Physical Health and Clinical Treatment Strategic Research Centre, School of Medicine, Deakin University , Geelong, VIC, Australia ; Mental Health and Wellbeing Strategic Research Centre, School of Psychology, Deakin University , Geelong, VIC, Australia.
Ajeet B SinghInnovation in Mental and Physical Health and Clinical Treatment Strategic Research Centre, School of Medicine, Deakin University , Geelong, VIC, Australia.
Julie A PascoInnovation in Mental and Physical Health and Clinical Treatment Strategic Research Centre, School of Medicine, Deakin University , Geelong, VIC, Australia ; Department of Medicine, NorthWest Academic Centre, University of Melbourne , St Albans, VIC, Australia.
Michael BerkInnovation in Mental and Physical Health and Clinical Treatment Strategic Research Centre, School of Medicine, Deakin University , Geelong, VIC, Australia ; Department of Psychiatry, University of Melbourne , Parkville, VIC, Australia ; Florey Institute for Neuroscience and Mental Health , Parkville, VIC, Australia ; Orygen, The National Centre of Excellence in Youth Mental Health , Parkville, VIC, Australia.
Louisa SylviaDepartment of Psychiatry, Massachusetts General Hospital , Boston, MA, USA ; Harvard Medical School, Harvard University , Boston, MA, USA.
Deakin University · AUMassachusetts General Hospital · USRMIT University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite evidence that exercise has been found to be effective in the treatment of depression, it is unclear whether these data can be extrapolated to bipolar disorder. Available evidence for bipolar disorder is scant, with no existing randomized controlled trials having tested the impact of exercise on depressive, manic or hypomanic symptomatology. Although exercise is often recommended in bipolar disorder, this is based on extrapolation from the unipolar literature, theory and clinical expertise and not empirical evidence. In addition, there are currently no available empirical data on program variables, with practical implications on frequency, intensity and type of exercise derived from unipolar depression studies. The aim of the current paper is to explore the relationship between exercise and bipolar disorder and potential mechanistic pathways. Given the high rate of medical co-morbidities experienced by people with bipolar disorder, it is possible that exercise is a potentially useful and important intervention with regard to general health benefits; however, further research is required to elucidate the impact of exercise on mood symptomology.

Indexed as

bipolar disorderdepressionexercisehypomaniamechanistic pathwaysneurogenesis

Identifiers

PMID25788889
PMCPMC4349127
OpenAlexW2028226240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.