Evidence map›Paper›PMID 25788884›Full record

ArticleFrontiers in human neuroscience2015

Self-regulation therapy increases frontal gray matter in children with fetal alcohol spectrum disorder: evaluation by voxel-based morphometry.

Debra W Soh, Jovanka Skocic, Kelly Nash, Sara Stevens, Gary R Turner, Joanne Rovet

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02457676 (Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02457676 nacompletednot on this map

Improving Self Regulation in Children With Fetal Alcohol Syndrome Spectrum Disorders: A Neuroplastic Intervention

TypeinterventionalSponsorThe Hospital for Sick ChildrenRan2009Enrolled65ConditionsFetal Alcohol Spectrum DisordersArmsAlert Program for Self-Regulation
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  5. Trial
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  7. Article
  8. Fetal alcohol spectrum disorders.Nature reviews. Disease primers · 2023
    Review
  9. Article
  10. Review
  11. Psychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Debra W SohDepartment of Psychology, York University Toronto, ON, Canada.
Jovanka SkocicNeurosciences and Mental Health Program, The Hospital for Sick Children Toronto, ON, Canada.
Kelly NashNeurosciences and Mental Health Program, The Hospital for Sick Children Toronto, ON, Canada ; Department of Applied Psychology and Human Development, The Ontario Institute of Studies in Education, University of Toronto ON, Canada.
Sara StevensNeurosciences and Mental Health Program, The Hospital for Sick Children Toronto, ON, Canada ; Department of Psychology, University of Toronto ON, Canada.
Gary R TurnerDepartment of Psychology, York University Toronto, ON, Canada.
Joanne RovetNeurosciences and Mental Health Program, The Hospital for Sick Children Toronto, ON, Canada ; Department of Psychology, University of Toronto ON, Canada ; Department of Pediatrics, University of Toronto ON, Canada.
Hospital for Sick Children · CAYork University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Children with fetal alcohol spectrum disorder show executive function (EF) deficits, particularly in self-regulation skills, and abnormalities in brain regions critical for these skills. None of the validated EF interventions for these children has been evaluated with regards to impacts on brain structure. Twenty-nine children with FASD were assigned to either an immediate-treatment (TX) or delayed-treatment control (DTC) group (DTC). Nineteen typically developing children served as healthy controls (CT). All received a structural MRI scan and baseline neuropsychological testing, following which the TX group underwent 12 weekly 1.5-h sessions of the Alert Program for Self-Regulation(®). After treatment or a period of ~14 weeks, all received a repeat scan and post-intervention testing. Whole-brain and region-of-interest analyses using voxel-based morphometry evaluated group differences and changes over time in gray matter (GM). Exploratory analyses revealed significant group changes: (1) At baseline, combined TX and DTC groups demonstrated global GM reductions compared with the CT group. (2) Region-of-interest analysis using a frontal mask, comparing post-intervention to pre-intervention results, showed significantly increased GM in the left middle frontal gyrus (BA10), right frontal pole (BA11), and right anterior cingulate (BA32) in the TX group. Similar results were not found in the DTC or CT groups. (3) At post-intervention, both TX and CT groups showed larger GM volumes than the DTC group in the left superior frontal gyrus (BA9), which was smaller in the FASD group at baseline. These results suggested that Alert led to improvements in post-intervention testing of self-regulation skills and typical brain development in treated children.

Indexed as

Alert therapyexecutive functioningFASDneuroplasticityself-regulation of emotionsVBM

Identifiers

PMID25788884
PMCPMC4349084
OpenAlexW1982564415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.