ReviewFrontiers in molecular neuroscience2015
cGMP in mouse rods: the spatiotemporal dynamics underlying single photon responses.
Review in Frontiers in molecular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction.JCI insight · 2024Article
- Rabconnectin-3α/DMXL2 Is Locally Enriched at the Synaptic Ribbon of Rod Photoreceptor Synapses.Cells · 2023Article
- Article
- Rhodopsin-mediated light-off-induced protein kinase A activation in mouse rod photoreceptor cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation.The EMBO journal · 2020Article
- Article
- Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp.Scientific reports · 2019Article
- Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods.PloS one · 2019Article
- Implications of dimeric activation of PDE6 for rod phototransduction.Open biology · 2018Article
- The discovery of the ability of rod photoreceptors to signal single photons.The Journal of general physiology · 2018Review
- Enhanced Mutant Compensates for Defects in Rhodopsin Phosphorylation in the Presence of Endogenous Arrestin-1.Frontiers in molecular neuroscience · 2018Article
- Fractional integral-like processing in retinal cones reduces noise and improves adaptation.PloS one · 2018Article
- REEP6 deficiency leads to retinal degeneration through disruption of ER homeostasis and protein trafficking.Human molecular genetics · 2017Article
- Compartmentalized cGMP Responses of Olfactory Sensory Neurons inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- How rods respond to single photons: Key adaptations of a G-protein cascade that enable vision at the physical limit of perception.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Editorial: Dynamics of cyclic nucleotide signaling in neurons.Frontiers in cellular neuroscience · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Vertebrate vision begins when retinal photoreceptors transduce photons into electrical signals that are then relayed to other neurons in the eye, and ultimately to the brain. In rod photoreceptors, transduction of single photons is achieved by a well-understood G-protein cascade that modulates cGMP levels, and in turn, cGMP-sensitive inward current. The spatial extent and depth of the decline in cGMP during the single photon response (SPR) have been major issues in phototransduction research since the discovery that single photons elicit substantial and reproducible changes in membrane current. The spatial profile of cGMP decline during the SPR affects signal gain, and thus may contribute to reduction of trial-to-trial fluctuations in the SPR. Here we summarize the general principles of rod phototransduction, emphasizing recent advances in resolving the spatiotemporal dynamics of cGMP during the SPR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.