Observational studyBMC anesthesiology2015
Required propofol dose for anesthesia and time to emerge are affected by the use of antiepileptics: prospective cohort study.
Observational study in BMC anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Comparison between oral midazolam versus oral ketamine plus midazolam as preanesthetic medication in autism spectrum disorder: double-blind randomized clinical trial.Brazilian journal of anesthesiology (Elsevier)Trial
- Dexmedetomidine produces more sleep-like brain activity compared with propofol in human participants.British journal of anaesthesia · 2026Article
- Perioperative Management of Patients With Seizure Disorders: Part II.Anesthesia progress · 2025Review
- Analogous cortical reorganization accompanies entry into states of reduced consciousness during anesthesia and sleep.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The Perioperative Anesthetic Management of the Pediatric Patient with Special Needs: An Overview of Literature.Children (Basel, Switzerland) · 2022Review
- Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Calcium channel blockers, angiotensin II receptor antagonists and alpha-blockers accentuate blood pressure reducing caused by dental local anesthesia.Clinical oral investigations · 2021Observational
- Delayed awakening time from general anesthesia for dental treatment of patients with disabilities.Journal of dental anesthesia and pain medicine · 2021Article
- Dental treatment under general anesthesia for patients with severe disabilities.Journal of dental anesthesia and pain medicine · 2021Review
- Case Studies Using the Electroencephalogram to Monitor Anesthesia-Induced Brain States in Children.Anesthesia and analgesia · 2020Review
- Cloning and characterization of the rat Slo3 (KBritish journal of pharmacology · 2020Article
- Cortical functional connectivity indexes arousal state during sleep and anesthesia.NeuroImage · 2020Article
- The number and kind of antiepileptics affect propofol dose requirement for anesthesia: observational study.Odontology · 2020Observational
- Effects site concentrations of propofol using target-controlled infusion in dental treatment under deep sedation among different intellectual disability types.Journal of dental anesthesia and pain medicine · 2019Article
- Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder.Frontiers in systems neuroscience · 2018Article
- Acoustic method respiratory rate monitoring is useful in patients under intravenous anesthesia.Journal of clinical monitoring and computing · 2017Observational
- [Influence of propofol dose and blood components on duration of electrical seizures in electroconvulsive therapy].Brazilian journal of anesthesiology (Elsevier)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the impact of the type of neurological disorder on the required propofol dose for anesthesia and the time to emerge from anesthesia during dental treatment in patients with autism (AU), cerebral palsy (CP), and intellectual disability (ID), some of whom also had epilepsy.
methodsWe studied 224 patients with a neurological disorder who underwent dental treatment under intravenous general anesthesia. Patients were categorized according to neurological disorder (AU, CP, and ID; and with or without an antiepileptic). The propofol dose required for anesthesia, time to emerge, and modeled propofol blood concentration at emergence were evaluated.
resultsIn patients not given an antiepileptic, we found no significant differences in the propofol dose, modeled propofol blood concentration at emergence, or time to emerge among patients with AU, CP, and ID (P > 0.05). When using an antiepileptic, the dose of propofol (5.7 ± 1.51 mg/kg/h) was significantly lower than without an antiepileptic (6.8 ± 1.27 mg/kg/h) (P < 0.0001). The modeled propofol blood concentration at emergence in patients given an antiepileptic (0.5 ± 0.03 μg/ml) was significantly lower than without an antiepileptic (0.7 ± 0.02 μg/ml) (P < 0.0001). The time to emerge in patients given an antiepileptic (29.5 ± 12.5 min) was significantly longer than without an antiepileptic (21.6 min ± 10.0 min) (P < 0.0001).
conclusionThe propofol dose required for anesthesia and the time to emerge from anesthesia are not affected by the type of neurological disorder, but are affected by antiepileptic use.
trial registrationUniversity Hospital Medical Information Network Clinical Trials Registry (UMIN000014179), Date of registration 4 June 2014.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.