Evidence map›Paper›PMID 25788574›Full record

ArticleAmerican journal of physiology. Cell physiology2015

A physical sciences network characterization of circulating tumor cell aggregate transport.

Michael R King, Kevin G Phillips, Annachiara Mitrugno, Tae-Rin Lee, Adelaide M E de Guillebon, Siddarth Chandrasekaran, Matthew J McGuire, Russell T Carr, Sandra M Baker-Groberg, Rachel A Rigg and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. The Applications and Challenges of the Development ofCellular and molecular bioengineering · 2023
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Michael R KingDepartment of Biomedical Engineering, Cornell University, Ithaca, New York;
Kevin G PhillipsDepartment of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, Oregon;
Annachiara MitrugnoDepartment of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, Oregon; Divison of Hematology and Medical Oncology, School of Medicine, Oregon Health and Science University, Portland, Oregon; and.
Tae-Rin LeeDepartment of Translational Imaging, The Methodist Hospital Research Institute, Houston, Texas;
Adelaide M E de GuillebonDepartment of Biomedical Engineering, Cornell University, Ithaca, New York;
Siddarth ChandrasekaranDepartment of Biomedical Engineering, Cornell University, Ithaca, New York;
Matthew J McGuireDepartment of Biomedical Engineering, Cornell University, Ithaca, New York;
Russell T CarrDepartment of Chemical Engineering, University of New Hampshire, Durham, New Hampshire.
Sandra M Baker-GrobergDepartment of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, Oregon;
Rachel A RiggDepartment of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, Oregon;
Anand KolatkarDepartment of Biological Sciences, University of Southern California, Los Angeles, California;
Madelyn LuttgenDepartment of Biological Sciences, University of Southern California, Los Angeles, California;
Kelly BethelScripps Clinic Medical Group, Scripps Clinic, La Jolla, California;
Peter KuhnDepartment of Biological Sciences, University of Southern California, Los Angeles, California;
Paolo DecuzziDepartment of Translational Imaging, The Methodist Hospital Research Institute, Houston, Texas;
Owen J T McCartyDepartment of Biomedical Engineering, School of Medicine, Oregon Health and Science University, Portland, Oregon; Divison of Hematology and Medical Oncology, School of Medicine, Oregon Health and Science University, Portland, Oregon; and mccartyo@ohsu.edu.
Oregon Health & Science University · USCornell University · USUniversity of Southern California · USHouston Methodist · USScripps Clinic Medical Group · USUniversity of New Hampshire · US

Funding

TRANS-NETWORK PROJECTSU54CA143876 · NCI · CORNELL UNIVERSITY · PI SHULER, MICHAEL L · 2009 to 2014
$12.6M
TRANS-NETWORK PROJECTSU54CA143837 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CURLEY, STEVEN ALAN · 2009 to 2014
$10.8M
TopologyU54CA143906 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KUHN, PETER · 2009 to 2014
$10.2M
Characterization of Coagulation Factor-platelet Interactions: Role of FXIR01HL101972 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Owen J McCarty · 2010 to 2026
$8.5M
NCI NIH HHS U54-CA-143837NCI NIH HHS U54-CA-143876NCI NIH HHS U54-CA-143906NHLBI NIH HHS R01-HL-101972
6 · The paper itself

Abstract

Circulating tumor cells (CTC) have been implicated in the hematogenous spread of cancer. To investigate the fluid phase of cancer from a physical sciences perspective, the multi-institutional Physical Sciences-Oncology Center (PS-OC) Network performed multidisciplinary biophysical studies of single CTC and CTC aggregates from a patient with breast cancer. CTCs, ranging from single cells to aggregates comprised of 2-5 cells, were isolated using the high-definition CTC assay and biophysically profiled using quantitative phase microscopy. Single CTCs and aggregates were then modeled in an in vitro system comprised of multiple breast cancer cell lines and microfluidic devices used to model E-selectin mediated rolling in the vasculature. Using a numerical model coupling elastic collisions between red blood cells and CTCs, the dependence of CTC vascular margination on single CTCs and CTC aggregate morphology and stiffness was interrogated. These results provide a multifaceted characterization of single CTC and CTC aggregate dynamics in the vasculature and illustrate a framework to integrate clinical, biophysical, and mathematical approaches to enhance our understanding of the fluid phase of cancer.

Indexed as

Cell MovementBreast NeoplasmsCell CountE-SelectinFemaleHumansMicrofluidic Analytical TechniquesNeoplastic Cells, CirculatingTranscytosisE-Selectinbreast cancercell linescirculating tumor cellfluid dynamicshemodynamicsimmersed finite element methodmetastasismicrofluidicsphysics of cancerquantitative phase microscopy

Identifiers

PMID25788574
PMCPMC4436994
OpenAlexW2003391471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.