ArticleOpen biology2015
The diatom-derived aldehyde decadienal affects life cycle transition in the ascidian Ciona intestinalis through nitric oxide/ERK signalling.
Article in Open biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Women researchers in tunicate biology at the Stazione Zoologica Anton Dohrn in Napoli.Genesis (New York, N.Y. : 2000) · 2023Article
- Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis.International journal of molecular sciences · 2022Article
- Transphyletic conservation of nitric oxide synthase regulation in cephalochordates and tunicates.Development genes and evolution · 2020Article
- Multiple Roles of Diatom-Derived Oxylipins within Marine Environments and Their Potential Biotechnological Applications.Marine drugs · 2020Review
- The complex evolutionary history of sulfoxide synthase in ovothiol biosynthesis.Proceedings. Biological sciences · 2019Article
- Biotic and environmental stress induces nitration and changes in structure and function of the sea urchin major yolk protein toposome.Scientific reports · 2018Article
- Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordateCommunications biology · 2018Article
- An ancient role for nitric oxide in regulating the animal pelagobenthic life cycle: evidence from a marine sponge.Scientific reports · 2016Article
- Subtle reproductive impairment through nitric oxide-mediated mechanisms in sea urchins from an area affected by harmful algal blooms.Scientific reports · 2016Article
- Shedding light on ovothiol biosynthesis in marine metazoans.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyunsaturated aldehydes (PUAs) are fatty-acid-derived metabolites produced by some microalgae, including different diatom species. PUAs are mainly produced as a wound-activated defence mechanism against microalgal predators or released from senescent cells at the end of a bloom. PUAs, including 2,4-trans-decadienal (DD), induce deleterious effects on embryonic and larval development of several planktonic and benthic organisms. Here, we report on the effects of DD on larval development and metamorphosis of the ascidian Ciona intestinalis. Ciona larval development is regulated by the cross-talking of different molecular events, including nitric oxide (NO) production, ERK activation and caspase 3-dependent apoptosis. We report that treatment with DD at the competence larval stage results in a delay in metamorphosis. DD affects redox balance by reducing total glutathione and NO levels. By biochemical and quantitative gene expression analysis, we identify the NO-signalling network affected by DD, including the upregulation of ERK phosphatase mkp1 and consequent reduction of ERK phosphorylation, with final changes in the expression of downstream ERK target genes. Overall, these results give new insights into the molecular pathways induced in marine organisms after exposure to PUAs during larval development, demonstrating that this aldehyde affects key checkpoints of larval transition from the vegetative to the reproductive life stage.
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