ArticleJournal of the American Society of Nephrology : JASN2015
Uric Acid and Cardiovascular Events: A Mendelian Randomization Study.
Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 161 papers, 8 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
161 citing papers in PubMed, 8 syntheses or guidelines pooled it, 295 citations in OpenAlex.
- Bempedoic Acid can Reduce Cardiovascular Events in Combination with Statins or As Monotherapy: A Systematic Review and Meta-analysis.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023 · on this mapPooled it
- Uric acid and risk of pre-eclampsia: results from a large case-control study and meta-analysis of prospective studies.Scientific reports · 2023Pooled it
- Cardiovascular Safety of Febuxostat and Allopurinol in Hyperuricemic Patients With or Without Gout: A Network Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Impact of Serum Uric Acid Lowering and Contemporary Uric Acid-Lowering Therapies on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Serum uric acid and risk of cardiovascular mortality: a systematic review and dose-response meta-analysis of cohort studies of over a million participants.BMC cardiovascular disorders · 2019Pooled it
- Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses.PloS one · 2018Pooled it
- Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies.BMJ (Clinical research ed.) · 2017Pooled it
- Association of Serum Uric Acid Levels in Psoriasis: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Evaluation of the Relationship Between Serum Urate Levels, Clinical Manifestations of Gout, and Death From Cardiovascular Causes in Patients Receiving Febuxostat or Allopurinol in an Outcomes Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2022Trial
- Differential effect of a xanthine oxidase inhibitor on arterial stiffness and carotid atherosclerosis: a subanalysis of the PRIZE study.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Trial
- Trial
- Effects of a Novel Fixed Combination of Nutraceuticals on Serum Uric Acid Concentrations and the Lipid Profile in Asymptomatic Hyperuricemic Patients : Results from the PICONZ-UA Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Trial
- Redefining Uric Acid and Cardiovascular Risk: Vascular Gout and Crystal-Driven Vascular Inflammation in Asymptomatic Hyperuricemia.JACC. Asia · 2026Review
- Metabolomic signatures prior to in-hospital cardiac arrest: insights into potential therapeutic targets.Scientific reports · 2026Article
- Gender differences in asymptomatic hyperuricemia's effects on left ventricular function and remodeling in hypertension: insights from cardiac MRI.BMC cardiovascular disorders · 2026Article
- The association of serum uric acid with severity and prognosis of patients with diabetic foot ulcers.Frontiers in endocrinology · 2026Article
- Hyperuricemia as an Early Indicator of Cardiovascular Risk in the General Population.Journal of clinical medicine · 2025Article
- Gender differences in the predictive value of serum uric acid for major adverse cardiovascular events in patients with acute coronary syndromes: a retrospective cohort study.BMC cardiovascular disorders · 2025Article
- The Impact of Hyperuricemia on the Progression of Atherosclerotic Cardiovascular Disease.Cureus · 2025Article
- Potential links between serum uric acid levels and testosterone levels in adult males: a cross-sectional study.Scientific reports · 2025Article
101 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and diets rich in uric acid-raising components appear to account for the increased prevalence of hyperuricemia in Westernized populations. Prevalence rates of hypertension, diabetes mellitus, CKD, and cardiovascular disease are also increasing. We used Mendelian randomization to examine whether uric acid is an independent and causal cardiovascular risk factor. Serum uric acid was measured in 3315 patients of the Ludwigshafen Risk and Cardiovascular Health Study. We calculated a weighted genetic risk score (GRS) for uric acid concentration based on eight uric acid-regulating single nucleotide polymorphisms. Causal odds ratios and causal hazard ratios (HRs) were calculated using a two-stage regression estimate with the GRS as the instrumental variable to examine associations with cardiometabolic phenotypes (cross-sectional) and mortality (prospectively) by logistic regression and Cox regression, respectively. Our GRS was not consistently associated with any biochemical marker except for uric acid, arguing against pleiotropy. Uric acid was associated with a range of prevalent diseases, including coronary artery disease. Uric acid and the GRS were both associated with cardiovascular death and sudden cardiac death. In a multivariate model adjusted for factors including medication, causal HRs corresponding to each 1-mg/dl increase in genetically predicted uric acid concentration were significant for cardiovascular death (HR, 1.77; 95% confidence interval, 1.12 to 2.81) and sudden cardiac death (HR, 2.41; 95% confidence interval, 1.16 to 5.00). These results suggest that high uric acid is causally related to adverse cardiovascular outcomes, especially sudden cardiac death.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.