ArticleDevelopmental neurobiology2015
Transient ipsilateral retinal ganglion cell projections to the brain: Extent, targeting, and disappearance.
Article in Developmental neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Development of the Binocular Circuit.Annual review of neuroscience · 2024Review
- Decreased CREB phosphorylation impairs embryonic retinal neurogenesis in thebioRxiv : the preprint server for biology · 2024Article
- CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm.Development (Cambridge, England) · 2024Article
- Multiomic Analysis of Neurons with Divergent Projection Patterns Identifies Novel Regulators of Axon Pathfinding.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types.eLife · 2022Article
- A cell-ECM mechanism for connecting the ipsilateral eye to the brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic control of retinal ganglion cell genesis.Cellular and molecular life sciences : CMLS · 2021Review
- Double UP: A Dual Color, Internally Controlled Platform forFrontiers in molecular neuroscience · 2020Article
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
- Distinct timing of neurogenesis of ipsilateral and contralateral retinal ganglion cells.The Journal of comparative neurology · 2019Article
- Assembly and repair of eye-to-brain connections.Current opinion in neurobiology · 2018Review
- Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway.The Journal of comparative neurology · 2018Article
- VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels.Development (Cambridge, England) · 2017Article
- Article
- Fasudil alleviates traumatic optic neuropathy by inhibiting Rho signaling pathway.International journal of clinical and experimental medicine · 2015Article
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Authors and funding
2 authors.
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Abstract
During development of the mammalian eye, the first retinal ganglion cells (RGCs) that extend to the brain are located in the dorsocentral (DC) retina. These RGCs extend to either ipsilateral or contralateral targets, but the ipsilateral projections do not survive into postnatal periods. The function and means of disappearance of the transient ipsilateral projection are not known. We have followed the course of this transient early ipsilateral cohort of RGCs, paying attention to how far they extend, whether they enter targets and if so, which ones, and the time course of their disappearance. The DC ipsilateral RGC axons were traced using DiI labeling at E13.5 and E15.5 to compare the proportion of ipsi- versus contralateral projections during the first period of growth. In utero electroporation of E12.5 retina with GFP constructs was used to label axons that could be visualized at succeeding time points into postnatal ages. Our results show that the earliest ipsilateral axons grow along the cellular border of the brain, and are segregated from the laterally positioned contralateral axons from the same retinal origin. In agreement with previous reports, although many early RGCs extend ipsilaterally, after E16 their number rapidly declines. Nonetheless, some ipsilateral axons from the DC retina enter the superior colliculus and arborize minimally, but very few enter the dorsal lateral geniculate nucleus and those that do extend only short branches. While the mechanism of selective axonal disappearance remains elusive, these data give further insight into establishment of the visual pathways.
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