Evidence map›Paper›PMID 25788253›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2015

Household transmissibility of avian influenza A (H7N9) virus, China, February to May 2013 and October 2013 to March 2014.

Y Yang, Y Zhang, L Fang, M E Halloran, M Ma, S Liang, E Kenah, T Britton, E Chen, J Hu and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Zoonotic diseases from birds to humans in Vietnam: possible diseases and their associated risk factors.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Review
  8. Article
  9. Comparison of methods to Estimate Basic Reproduction Number (Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2019
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 3 countries.

Y YangDepartment of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States.
Y Zhang
L Fang
M E Halloran
M Ma
S Liang
E Kenah
T Britton
E Chen
J Hu
F Tang
W Cao
Z Feng
I M Longini
Institute of Microbiology · CNUniversity of Florida · USChinese Center For Disease Control and Prevention · CNFred Hutch Cancer Center · USJiangsu Provincial Center for Disease Control and Prevention · CNShanghai Municipal Center For Disease Control Prevention · CNStockholm University · SEUniversity of Florida Health · USZhejiang Center for Disease Control and Prevention · CN

Funding

Understanding Transmission with Integrated Genetic and Epidemiologic InferenceU54GM111274 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI VESPIGNANI, ALESSANDRO · 2014 to 2018
$12.5M
Containing Bioterrorist and Emerging Infectious DiseasesU01GM070749 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HALLORAN, M ELIZABETH, LONGINI, IRA M · 2004 to 2013
$8.3M
Methods for Evaluating Vaccine EfficacyR37AI032042 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HALLORAN, M ELIZABETH · 2010 to 2019
$5.1M
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
Survival analysis and regression in infectious disease epidemiologyR00AI095302 · NIAID · UNIVERSITY OF FLORIDA · PI KENAH, EBEN · 2012 to 2013
$445k
Survival analysis and regression in infectious disease epidemiologyK99AI095302 · NIAID · UNIVERSITY OF WASHINGTON · PI KENAH, EBEN · 2011 to 2011
$120k
NIAID NIH HHS K99 AI095302NIAID NIH HHS K99/R00 AI095302NIAID NIH HHS R00 AI095302NIAID NIH HHS R37 AI032042NIAID NIH HHS R37-AI032042NIGMS NIH HHS U01 GM070749NIGMS NIH HHS U54 GM111274NIGMS NIH HHS U54-GM111274NIH HHS S10 OD020069
6 · The paper itself

Abstract

To study human-to-human transmissibility of the avian influenza A (H7N9) virus in China, household contact information was collected for 125 index cases during the spring wave (February to May 2013), and for 187 index cases during the winter wave (October 2013 to March 2014). Using a statistical model, we found evidence for human-to-human transmission, but such transmission is not sustainable. Under plausible assumptions about the natural history of disease and the relative transmission frequencies in settings other than household, we estimate the household secondary attack rate (SAR) among humans to be 1.4% (95% CI: 0.8 to 2.3), and the basic reproductive number R0 to be 0.08 (95% CI: 0.05 to 0.13). The estimates range from 1.3% to 2.2% for SAR and from 0.07 to 0.12 for R0 with reasonable changes in the assumptions. There was no significant change in the human-to-human transmissibility of the virus between the two waves, although a minor increase was observed in the winter wave. No sex or age difference in the risk of infection from a human source was found. Human-to-human transmissibility of H7N9 continues to be limited, but it needs to be closely monitored for potential increase via genetic reassortment or mutation.

Indexed as

Models, BiologicalAnimalsChinaDisease OutbreaksFamily CharacteristicsFemaleGenome, ViralHumansInfluenza A Virus, H7N9 SubtypeInfluenza, HumanInfluenza in BirdsMaleMiddle AgedPopulation SurveillancePoultryReverse Transcriptase Polymerase Chain Reaction

Identifiers

PMID25788253
PMCPMC4404303
OpenAlexW2052271455

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.