ArticleHepatology international2015
High rate of core promoter and precore mutations in patients with chronic hepatitis B.
Article in Hepatology international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Impact of PC/BCP Mutations on Seroconversion and Relapse in HBeAg-Positive Chronic Hepatitis B Patients Treated with Nucleoside Analogues.Infection and drug resistance · 2025Article
- Hepatitis B virus strains from Rwandan blood donors are genetically similar and form one clade within subgenotype A1.BMC infectious diseases · 2017Article
- Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patients.World journal of gastroenterology · 2016Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundThe prevalence of precore (PC) and core promoter (CP) mutations in patients with chronic hepatitis B virus (HBV) infection (CHB) and their impact on liver disease is incompletely defined in the United States.
methodsA retrospective chart review using a cross-sectional approach of 1,186 CHB patients was conducted.
resultsOf 926 patients tested for HBV e antigen (HBeAg), 37% were HBeAg+. Of 194 patients tested for mutations, 80% had PC or CP mutations or both; 89% of HBeAg-negative and 56% of HBeAg+ patients had PC or CP mutations or both (p < 0.001). The mean log10 ALT was significantly lower in patients with both mutations compared to patients without mutations. The mean log10 HBV DNA was significantly lower in patients with only PC mutations (4.82) compared to patients without mutations (5.71, p = 0.019). With the study population divided into four subgroups based on ALT level at time of diagnosis, cirrhosis incidence was significantly higher in patients with ALT 1-2 × ULN and ALT > 2 × ULN compared to patients with ALT ≤ 0.5 × ULN.
conclusionsOur finding that PC and CP mutations may be associated with milder liver disease in some patients could serve as the basis for longitudinal studies to help delineate treatment need and duration in patients with these mutations. If confirmed, the finding of an association between ALT 1-2 × ULN and increased incidence of cirrhosis could call into question guidelines which only recommend treatment with ALT > 2 × ULN.
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