ArticleJournal of neurophysiology2015
Adaptive shaping of cortical response selectivity in the vibrissa pathway.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Alpha Modulation of Spiking Activity Across Multiple Brain Regions in Mice Performing a Tactile Selective Detection Task.The European journal of neuroscience · 2025Article
- The interaction between neurotransmitter receptor activity and amyloid-β pathology in Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2025Review
- Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Bidirectional modulation of somatostatin-expressing interneurons in the basolateral amygdala reduces neuropathic pain perception in mice.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- MULTIPLE DISTINCT TIMESCALES OF RAPID SENSORY ADAPATION IN THE THALAMOCORTICAL CIRCUIT.bioRxiv : the preprint server for biology · 2024Article
- Optimization of Temporal Coding of Tactile Information in Rat Thalamus by Locus Coeruleus Activation.Biology · 2024Article
- Adaptive decision-making depends on pupil-linked arousal in rats performing tactile discrimination tasks.Journal of neurophysiology · 2023Article
- Mechanisms of human dynamic object recognition revealed by sequential deep neural networks.PLoS computational biology · 2023Article
- Adaptive control of synaptic plasticity integrates micro- and macroscopic network function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Rapid Effects of Vagus Nerve Stimulation on Sensory Processing Through Activation of Neuromodulatory Systems.Frontiers in neuroscience · 2022Review
- Rapid Cortical Adaptation and the Role of Thalamic Synchrony during Wakefulness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation.Nature biomedical engineering · 2021Article
- Sensory Adaptation in the Whisker-Mediated Tactile System: Physiology, Theory, and Function.Frontiers in neuroscience · 2021Review
- Interplay between components of pupil-linked phasic arousal and its role in driving behavioral choice in Go/No-Go perceptual decision-making.Psychophysiology · 2020Article
- Perceptual Behavior Depends Differently on Pupil-Linked Arousal and Heartbeat Dynamics-Linked Arousal in Rats Performing Tactile Discrimination Tasks.Frontiers in systems neuroscience · 2020Article
- Pupil-linked arousal modulates behavior in rats performing a whisker deflection direction discrimination task.Journal of neurophysiology · 2018Article
- Olfactory coding in the turbulent realm.PLoS computational biology · 2017Article
- Network activity influences the subthreshold and spiking visual responses of pyramidal neurons in the three-layer turtle cortex.Journal of neurophysiology · 2017Article
- Dynamic Lateralization of Pupil Dilation Evoked by Locus Coeruleus Activation Results from Sympathetic, Not Parasympathetic, Contributions.Cell reports · 2017Article
- Voltage-sensitive dye imaging of mouse neocortex during a whisker detection task.Neurophotonics · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
One embodiment of context-dependent sensory processing is bottom-up adaptation, where persistent stimuli decrease neuronal firing rate over hundreds of milliseconds. Adaptation is not, however, simply the fatigue of the sensory pathway, but shapes the information flow and selectivity to stimulus features. Adaptation enhances spatial discriminability (distinguishing stimulus location) while degrading detectability (reporting presence of the stimulus), for both the ideal observer of the cortex and awake, behaving animals. However, how the dynamics of the adaptation shape the cortical response and this detection and discrimination tradeoff is unknown, as is to what degree this phenomenon occurs on a continuum as opposed to a switching of processing modes. Using voltage-sensitive dye imaging in anesthetized rats to capture the temporal and spatial characteristics of the cortical response to tactile inputs, we showed that the suppression of the cortical response, in both magnitude and spatial spread, is continuously modulated by the increasing amount of energy in the adapting stimulus, which is nonuniquely determined by its frequency and velocity. Single-trial ideal observer analysis demonstrated a tradeoff between detectability and spatial discriminability up to a moderate amount of adaptation, which corresponds to the frequency range in natural whisking. This was accompanied by a decrease in both detectability and discriminability with high-energy adaptation, which indicates a more complex coupling between detection and discrimination than a simple switching of modes. Taken together, the results suggest that adaptation operates on a continuum and modulates the tradeoff between detectability and discriminability that has implications for information processing in ethological contexts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.